null

SMILES O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1

InChI Key InChIKey=IBGLGMOPHJQDJB-IHRRRGAJSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50364378   

TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataKi:  6.20nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829SKPubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataKi:  44nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of hexa-His-tagged JNK3 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of p38alpha using myelin basic protein as substrate preincubated for 15 mins prior ATP addition measured after 60 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829SKPubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829SKPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829SKPubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J7NPubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J7NPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J7NPubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Mus musculus)TBA
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of JNK1 in mouse RAW264.7 cells assessed as inhibition of c-Jun phosphorylation incubated for 30 mins by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19CXPubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 133nMAssay Description:Inhibition of JNK1 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19CXPubMed
TargetMitogen-activated protein kinase 8(Mus musculus)TBA
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of c-Jun phosphorylation in LPS-stimulated JNK1-/- mouse embryonic fibroblast incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19CXPubMed
TargetMitogen-activated protein kinase 8(Mus musculus)TBA
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of c-Jun phosphorylation in LPS-stimulated JNK2-/- mouse embryonic fibroblast incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19CXPubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Celgene Corporation

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829SKPubMed