null

SMILES NC(c1csc(c1)C(=O)c1cncnc1N[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)C1)c1cccc(Cl)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50575582   

TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50575582(CHEMBL4862248)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant SAE (unknown origin) assessed as reduction in transfer of SUMO1 to UBC9 using SUMO1 as a substrate in presence of ATP at Km...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KZ8PubMed
TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50575582(CHEMBL4862248)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant SAE (unknown origin) assessed as reduction in transfer of SUMO1 to UBC9 using SUMO1 as a substrate in presence of ATP at Km...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KZ8PubMed
LigandPNGBDBM50575582(CHEMBL4862248)copy SMILES
Affinity DataIC50: 328nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KZ8PubMed
TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50575582(CHEMBL4862248)copy SMILES
Affinity DataIC50: 499nMAssay Description:Inhibition of SAE in human HCT116 cells assessed as redistribution of SUMO2/3 proteins from nucleus to cytosol preincubated for 2 hrs followed by com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KZ8PubMed
TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50575582(CHEMBL4862248)copy SMILES
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of SAE in human HCT116 cells assessed as reduction in redistribution of SUMO2/3 proteins from nucleus to cytosol incubated for 4 hrs by im...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KZ8PubMed
TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50575582(CHEMBL4862248)copy SMILES
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of SAE in human HCT116 cells assessed as reduction in redistribution of SUMO2/3 proteins from nucleus to cytosol incubated for 4 hrs by im...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KZ8PubMed
TargetSUMO-activating enzyme subunit 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50575582(CHEMBL4862248)copy SMILES
Affinity DataIC50: 83nMAssay Description:Inhibition of SAE in human HCT116 cells assessed as redistribution of SUMO2/3 proteins from nucleus to cytosol preincubated for 2 hrs followed by com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KZ8PubMed
LigandPNGBDBM50575582(CHEMBL4862248)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KZ8PubMed