null

SMILES CCN1CCC(COc2ccc(Nc3cc(c(F)cn3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 556330   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM556330(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)copy SMILES
Affinity DataIC50: 0.100nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PTPUS Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM556330(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)copy SMILES
Affinity DataIC50: 11.3nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PTPUS Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM556330(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)copy SMILES
Affinity DataIC50: 24.7nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PTPUS Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM556330(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)copy SMILES
Affinity DataIC50: 2.90nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PTPUS Patent