null

SMILES CO[C@@H](C)c1ncccc1-c1c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3nc(cs3)-c3ccc(n1CC(F)(F)F)c2c3)NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)\C=C\CN(C)C)C2(CC2)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 591984   

TargetGTPase KRas [G12D](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase NRas(Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase KRas [G13C](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase KRas [G13D](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase NRas [Q61R](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase KRas [G12V](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 550nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase NRas [G12C](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase KRas [G12S](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase NRas [Q61K](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent
TargetGTPase KRas [Q61H](Homo sapiens (Human))TBA
LigandPNGBDBM591984(US11566007, Example A664)copy SMILES
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP06QHUS Patent