Compile Data Set for Download or QSAR
Found 298 with Last Name = 'deangelis' and Initial = 'a'
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK5/p35More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133057(17,20,23-trioxa-4,14,26-triazahexacyclo[24.6.1.17,...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration of compound against CDK2/cyclin AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133059(17,20,23-trioxa-4,12,14,26-tetraazahexacyclo[24.6....)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of Glycogen synthase kinase-3beta (GSK3-beta)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of cyclin dependent kinase CDK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133061(17,20,23,26-tetraoxa-4,14,29-triazahexacyclo[27.6....)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of Glycogen synthase kinase-3beta (GSK3-beta)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133064(17,20,23-trioxa-4,12,14,26,28-pentaazahexacyclo[24...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of Glycogen synthase kinase-3beta (GSK3-beta)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133059(17,20,23-trioxa-4,12,14,26-tetraazahexacyclo[24.6....)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133058(17,20,23,26-tetraoxa-4,12,14,29,31-pentaazahexacyc...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of Glycogen synthase kinase-3beta (GSK3-beta)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133065(17,20,23,26,29-pentaoxa-4,14,32-triazahexacyclo[30...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of Glycogen synthase kinase-3beta (GSK3-beta)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169895(3-{5-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of cyclin dependent kinase (CDK1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6417(4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133057(17,20,23-trioxa-4,14,26-triazahexacyclo[24.6.1.17,...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Inhibition of Protein kinase C thetaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6421(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6419(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6391((3-Chloro-phenyl)-{6-[5-(3-pyridin-4-yl-propylamin...)copy SMILEScopy InChI
Affinity DataIC50: 76nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6416(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 84nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56NCPubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6416(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 84nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133057(17,20,23-trioxa-4,14,26-triazahexacyclo[24.6.1.17,...)copy SMILEScopy InChI
Affinity DataIC50: 86nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6420(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6418(N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]a...)copy SMILEScopy InChI
Affinity DataIC50: 105nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6408((3-Chlorophenyl)-(6-{5-[3-(4-methyl-piperazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 123nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:Inhibition of CDK7/cyclin HMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6398(N-(3-chlorophenyl)-6-(5-{[3-(dimethylamino)propyl]...)copy SMILEScopy InChI
Affinity DataIC50: 135nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133063(17,20-dioxa-4,14,23-triazahexacyclo[21.6.1.17,14.0...)copy SMILEScopy InChI
Affinity DataIC50: 136nMAssay Description:Inhibition of Glycogen synthase kinase-3beta (GSK3-beta)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133067(17,20-dioxa-4,12,14,23-tetraazahexacyclo[21.6.1.17...)copy SMILEScopy InChI
Affinity DataIC50: 138nMAssay Description:Inhibition of Glycogen synthase kinase-3beta (GSK3-beta)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6421(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 153nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6388(3-[(5-{6-[(3-fluorophenyl)amino]pyrazin-2-yl}pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 168nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6409(N-(3-chlorophenyl)-6-(5-{[3-(morpholin-4-yl)propyl...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6393((3,4-Dichloro-phenyl)-{6-[5-(3-pyridin-4-yl-propyl...)copy SMILEScopy InChI
Affinity DataIC50: 189nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetGlycogen synthase kinase-3 beta [7-25](Oryctolagus cuniculus (rabbit))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6421(N-(3-Chlorophenyl)-6-[5-[[3-(1H-1,2,4-triazol-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 196nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6416(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56NCPubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6416(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50133057(17,20,23-trioxa-4,14,26-triazahexacyclo[24.6.1.17,...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of Glycogen synthase kinase-3beta (GSK3-beta)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6407(N-(3-Chlorophenyl)-6-[5-[[3-(1-piperazinyl)propyl]...)copy SMILEScopy InChI
Affinity DataIC50: 236nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6423(3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-6-fl...)copy SMILEScopy InChI
Affinity DataIC50: 251nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6412(N-(3-Chlorophenyl)-6-[5-[[4-(4-pyridinyl)butyl]ami...)copy SMILEScopy InChI
Affinity DataIC50: 266nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6397(2-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 275nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6419(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)copy SMILEScopy InChI
Affinity DataIC50: 293nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of Protein kinase C gamma (PKC-gamma)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6402(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)copy SMILEScopy InChI
Affinity DataIC50: 303nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 308nMAssay Description:Inhibition of CDK4/cyclin D1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetGlycogen synthase kinase-3 beta [7-25](Oryctolagus cuniculus (rabbit))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6419(N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]am...)copy SMILEScopy InChI
Affinity DataIC50: 318nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6420(N-(3-Chlorophenyl)-6-[5-[[3-(1H-pyrazol-1-yl)propy...)copy SMILEScopy InChI
Affinity DataIC50: 326nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169896(3-{5-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-ylamino)-[...)copy SMILEScopy InChI
Affinity DataIC50: 344nMAssay Description:Inhibition of cyclin dependent kinase (CDK1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6401(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)copy SMILEScopy InChI
Affinity DataIC50: 346nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NC5ZD5PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 356nMAssay Description:Inhibition of CDK6/cyclin D3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833RK0PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44R1DPubMed
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