TargetHistone deacetylase 3(Homo sapiens (Human))
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC3 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC3 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC3 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) incubated for 15 mins before substrate addition and measured after 30 to 45 mins by HDAC-Glo substra...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin)incubated for 15 mins before substrate addition and measured after 30 to 45 mins by HDAC-Glo substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin)incubated for 15 mins before substrate addition and measured after 30 to 45 mins by HDAC-Glo substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of HDAC6 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HDAC1 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HDAC6 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HDAC1 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HDAC6 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of HDAC1 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of wild-type FLAG-tagged HDAC1 (unknown origin) expressed in Jurkat cells after 2 hrs by Fluor de lys staining-based fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, United States.
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin)incubated for 15 mins before substrate addition and measured after 30 to 45 mins by HDAC-Glo substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) incubated for 15 mins before substrate addition and measured after 30 to 45 mins by HDAC-Glo substra...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin)incubated for 15 mins before substrate addition and measured after 30 to 45 mins by HDAC-Glo substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 88nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of HDAC2 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of HDAC2 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of HDAC2 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC6 in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 40 mins by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of HDAC in human HeLa-S3 cell lysates preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 35 mins by fluorimet...More data for this Ligand-Target Pair
Affinity DataIC50: 204nMAssay Description:Inhibition of FLAG-tagged HDAC1 S113A mutant (unknown origin) expressed in Jurkat cells after 2 hrs by Fluor de lys staining-based fluorimetric analy...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of HDAC6 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of HDAC6 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of full length human C-terminal His-tag HDAC8 expressed in baculovirus expression system preincubated for 15 mins followed by HDAC-Glo sub...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of HDAC8 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of HDAC6 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of HDAC8 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of HDAC8 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cell preincubated for 15 mins fo...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2Z3228HPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2Z3228HPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
Affinity DataIC50: 540nMAssay Description:Inhibition of full length human C-terminal His-tag HDAC8 expressed in baculovirus expression system preincubated for 15 mins followed by HDAC-Glo sub...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2KS6TQFPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2KS6TQFPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
Affinity DataIC50: 540nMAssay Description:Inhibition of HDAC8 (unknown origin) by ELISA-based assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q22R3V5JPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q22R3V5JPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
Affinity DataIC50: 600nMAssay Description:Inhibition of HDAC6 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 710nMAssay Description:Inhibition of full length human C-terminal His-tag HDAC8 expressed in baculovirus expression system preincubated for 15 mins followed by HDAC-Glo sub...More data for this Ligand-Target Pair
![](/img/powered_by_small.gif)