TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 3.30nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 3.40nMAssay Description:Inhibition of human full-length recombinant HDAC6 expressed in baculovirus infected Sf9 insect cells using Boc-Lys (Ac)-AMC as substrate preincubated...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 7.60nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus-infected Sf9 insect cells using RHKK(Ac)AMC as subst...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human HDAC6 pre-incubated for 5 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 2nMT: 2°CAssay Description:Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human HDAC6 using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductaseMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human full length recombinant HDAC6 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC6 in mouse N2A cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate 3 pre-incubated for 30 mins followed by HDAC developer addition and measured a...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of choline acetyltransferase (CAT) enzymeMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against acetylcholinetransferase (AChE) enzymeMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 13.7nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in Sf9 cells using RHKK(Ac) as substrate after 90 mins by fluorimet...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 14nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human HDAC6 using fluorogenic-(RHKKAc) as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human KDAC6 using acetylated p53 (379 to 382 residues) as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant N-GST-tagged HDAC6 (unknown origin) assessed as reduction in deacetylation of Ac-Arg-Gly-Lys(Ac)-AMC substrate by fluoresce...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human HDAC6 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human HDAC6 using RHKKAc peptide as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 using RHKKAc peptide as substrate incubated for 5 to mins prior to substrate addition measured after 2 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(acetyl)-AMC as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant full-length HDAC6 expressed in baculovirus infected Sf9 cells using Boc-Lys(acetyl)-AMC as substrate after 30 mins by...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 using RHKKAcAMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human HDAC6 using RHKKAc fluorogenic peptide substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human HDAC6 using fluorogenic HDAC substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human HDAC6 using p53 fluorogenic peptide (379 to 382 residues) RHKKAc as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair