TargetProprotein convertase subtilisin/kexin type 7(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC7 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 5(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC6 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetNeuroendocrine convertase 2(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataKi: 0.360nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC2 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC1 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetNeuroendocrine convertase 1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC3 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataKi: 3.60nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC4 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataKi: 1.00E+4nMAssay Description:Binding affinity to AT1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP 695 assessed as reduction in amyloid beta levels after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 0.270nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch activationMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 0.390nMAssay Description:Inhibition of gamma secretase mediated Notch signaling in HEK293 cells after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 0.410nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch signalingMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of gamma secretase in human SupT1 cells assessed as reduction in amyloid beta 40 after 16 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of gamma secretase mediated Notch signaling in human SupT1 cells after 16 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human gamma secretase expressing APP751 by electrochemiluminescence assayMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma secretase in human MCF7 cells assessed as reduction in amyloid beta 40 after 3 days by Western blot analysisMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of ADAM10 (unknown origin) assessed as blockage of TNF-alpha sheddingMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of gamma secretase isolated from human HeLa cell derived P2 membrane assessed as reduction in amyloid beta (1 to 40 residues) using recomb...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma secretase (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of tankyrase1/2 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in amyloid beta levels by sandwich ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch signalingMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated APP cleavage in CHO cells expressing APP Swedish KM/NL mutant assessed as reduction in amyloi...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in amyloid beta levels by HTRF assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human S1P2 receptorMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat S1P2 receptorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP assessed as reduction in amyloid beta levelsMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Inhibition of full-length human gamma secretase expressed in SH-SY5Y spbetaA4CTF cells assessed as reduction in amyloid beta levels after 90 mins by ...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Inhibition of gamma secretase in human primary neuronal cells assessed as reduction in amyloid beta 40More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Modulation of gamma secretase in HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta levels after 5 hrsMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 209nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch M1726V mutant activation in CHO K1 cells after 48 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch signaling by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 541nMAssay Description:Inhibition of ADAM17 (unknown origin) assessed as blockage of TNF-alpha sheddingMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of gamma secretase mediated Notch delta E activation in human HeLa cells expressing EGFP after 16 hrs by immunofluorescence analysisMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CBP (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of ADAM17 (unknown origin) assessed as blockage of TNF-alpha sheddingMore data for this Ligand-Target Pair
TargetSphingosine kinase 2(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Centre Hospitalier Universitaire Vaudois (CHUV)
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of gamma secretase mediated amyloid beta level reduction in HEK293 cells expressing APP after 72 hrs by chemiluminescence assayMore data for this Ligand-Target Pair