Compile Data Set for Download or QSAR
Found 102 with Last Name = 'benoit' and Initial = 'e'
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235671(CHEMBL4097212)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235661(CHEMBL4088796)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235667(CHEMBL4080688)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235670(CHEMBL4079988)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235673(CHEMBL4060572)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235668(CHEMBL4098946)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235672(CHEMBL4061606)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235674(CHEMBL4070018)copy SMILEScopy InChI
Affinity DataKi:  90nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235664(CHEMBL4083422)copy SMILEScopy InChI
Affinity DataKi:  90nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235665(CHEMBL4104227)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Inhibition of Endothelin-converting enzyme of guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235669(CHEMBL4080910)copy SMILEScopy InChI
Affinity DataKi:  200nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM768(4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one | CH...)copy SMILEScopy InChI
Affinity DataKi:  200nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235663(CHEMBL4070271)copy SMILEScopy InChI
Affinity DataKi:  260nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)copy SMILEScopy InChI
Affinity DataKi:  600nM ΔG°:  -36.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27943HCPubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)copy SMILEScopy InChI
Affinity DataKi:  1.80E+3nM ΔG°:  -34.1kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27943HCPubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235662(CHEMBL4091210)copy SMILEScopy InChI
Affinity DataKi:  3.90E+3nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Universit£ Claude Bernard Lyon 1

Curated by ChEMBL
LigandPNGBDBM50235666(CHEMBL4104918)copy SMILEScopy InChI
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP7764PubMed
TargetVitamin K epoxide reductase complex subunit 1-like protein 1(Rattus norvegicus (Rat))
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)copy SMILEScopy InChI
Affinity DataKi:  3.26E+4nM ΔG°:  -26.6kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27943HCPubMed
TargetVitamin K epoxide reductase complex subunit 1-like protein 1(Homo sapiens (Human))
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)copy SMILEScopy InChI
Affinity DataKi:  5.20E+4nM ΔG°:  -25.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27943HCPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377836(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(4...)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521321(CHEMBL4442732)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521322(CHEMBL4436118)copy SMILEScopy InChI
Affinity DataIC50: 0.370nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521317(CHEMBL4559065)copy SMILEScopy InChI
Affinity DataIC50: 0.410nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50512857(CHEMBL4456283 | US10815213, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521315(CHEMBL4469663)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50512857(CHEMBL4456283 | US10815213, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521318(CHEMBL4440096 | US10815213, Example 151)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521314(CHEMBL4556666 | US10815213, Example 145)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521322(CHEMBL4436118)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521313(CHEMBL4572913)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521322(CHEMBL4436118)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged SRC cytoplasmic domain expressed in baculovirus expression system using FAM-Srctide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521311(CHEMBL4591391 | US10815213, Example 150)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521315(CHEMBL4469663)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377824((R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)copy SMILEScopy InChI
Affinity DataIC50: 7.60nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377836(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(4...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human EGFR cytoplasmic domain expressed in baculovirus expression system using FITC-C6-KKAEEEEYFELVAKK-NH2 as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521321(CHEMBL4442732)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human EGFR cytoplasmic domain expressed in baculovirus expression system using FITC-C6-KKAEEEEYFELVAKK-NH2 as substrate preincubated fo...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377824((R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50512857(CHEMBL4456283 | US10815213, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-human IgE antibody-stimulated histamine release pretreated for 2 hrs followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521321(CHEMBL4442732)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human EGFR cytoplasmic domain expressed in baculovirus expression system using FITC-C6-KKAEEEEYFELVAKK-NH2 as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521318(CHEMBL4440096 | US10815213, Example 151)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged SRC cytoplasmic domain expressed in baculovirus expression system using FAM-Srctide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
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