Compile Data Set for Download or QSAR
Found 442 with Last Name = 'specker' and Initial = 'e'
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590085(CHEMBL5187102)copy SMILES
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM12372(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]meth...)copy SMILEScopy InChI
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM12400(1-[(4-Chloro-phenylcarbamoyl)-methyl]-1H-indole-2-...)copy SMILEScopy InChI
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590072(CHEMBL3904655)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590086(CHEMBL5192536)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590082(CHEMBL5175184)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590073(CHEMBL5175600)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590087(CHEMBL5179837)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590097(CHEMBL5187449)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590083(CHEMBL5192808)copy SMILES
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590078(CHEMBL5175799)copy SMILES
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590081(CHEMBL5180386)copy SMILES
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590099(CHEMBL5193338)copy SMILES
Affinity DataKi:  37nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8117(Hydroxyethylene Sulfone 17b | N-[(2S,3R,5S)-1-(3-b...)copy SMILEScopy InChI
Affinity DataKi:  45nM ΔG°:  -41.9kJ/mole IC50: 85nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590075(CHEMBL5190215)copy SMILES
Affinity DataKi:  49nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590084(CHEMBL5208176)copy SMILES
Affinity DataKi:  51nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590089(CHEMBL5181980)copy SMILES
Affinity DataKi:  52nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590080(CHEMBL5185736)copy SMILES
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590074(CHEMBL5187415)copy SMILES
Affinity DataKi:  56nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590088(CHEMBL5192209)copy SMILES
Affinity DataKi:  57nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590071(CHEMBL5178354)copy SMILES
Affinity DataKi:  63nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590096(CHEMBL5173515)copy SMILES
Affinity DataKi:  65nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590077(CHEMBL5188689)copy SMILES
Affinity DataKi:  70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590076(CHEMBL5204725)copy SMILES
Affinity DataKi:  162nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590079(CHEMBL5193560)copy SMILES
Affinity DataKi:  188nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590070(CHEMBL5206688)copy SMILES
Affinity DataKi:  204nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590093(CHEMBL5186260)copy SMILES
Affinity DataKi:  204nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590095(CHEMBL5199539)copy SMILES
Affinity DataKi:  241nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8123(Hydroxyethylene Sulfone 18a | N-((1S,2R,4S)-1-(3-b...)copy SMILEScopy InChI
Affinity DataKi:  370nM ΔG°:  -36.7kJ/mole IC50: 530nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416V8DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8124(Hydroxyethylene Sulfone 18b | N-((1S,2R,4S)-1-(3-b...)copy SMILEScopy InChI
Affinity DataKi:  540nM ΔG°:  -35.8kJ/mole IC50: 790nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416V8DPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590098(CHEMBL5194849)copy SMILES
Affinity DataKi:  1.24E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8118(Hydroxyethylene Sulfone 17b- | N-[(2R,3S,5R)-1-(3-...)copy SMILEScopy InChI
Affinity DataKi:  1.40E+3nM ΔG°:  -33.4kJ/mole IC50: 2.00E+3nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416V8DPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590092(CHEMBL5205467)copy SMILES
Affinity DataKi:  1.74E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8121((2R)-N-[(2S,3R,5S)-1-(3-bromophenyl)-7-(2,4-dichlo...)copy SMILEScopy InChI
Affinity DataKi:  2.90E+3nM ΔG°:  -31.6kJ/mole IC50: 4.20E+3nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416V8DPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590091(CHEMBL5202796)copy SMILES
Affinity DataKi:  2.93E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8120(2-bromo-N-[(2S,3R,5S)-1-(3-bromophenyl)-7-(2,4-dic...)copy SMILEScopy InChI
Affinity DataKi:  3.10E+3nM ΔG°:  -31.4kJ/mole IC50: 4.50E+3nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416V8DPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590090(CHEMBL5175878)copy SMILES
Affinity DataKi:  5.13E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8119(Hydroxyethylene Sulfone 17c | N-[(2S,3R,5S)-1-(3-b...)copy SMILEScopy InChI
Affinity DataKi:  7.00E+3nM ΔG°:  -29.4kJ/mole IC50: 1.00E+4nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416V8DPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590100(CHEMBL5176283)copy SMILES
Affinity DataKi:  1.48E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50590094(CHEMBL5205339)copy SMILES
Affinity DataKi:  2.05E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP06RZPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8122((2R)-N-[(2R,3S,5R)-1-(3-bromophenyl)-7-(2,4-dichlo...)copy SMILEScopy InChI
Affinity DataKi: >4.00E+4nM ΔG°: >-25.1kJ/mole IC50: 4.00E+4nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416V8DPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8116(Hydroxyethylene Sulfone 17a | N-[(2S,3R,5S)-1-(3-b...)copy SMILEScopy InChI
Affinity DataKi: >4.00E+4nM ΔG°: >-25.1kJ/mole IC50: 4.00E+4nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416V8DPubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent
LigandPNGBDBM445676(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4TQ6US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent
LigandPNGBDBM445676(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM2DRCUS Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent
LigandPNGBDBM357737(KM-05-166/(I-206) | US10214530, Example 24)copy SMILEScopy InChI
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164VFPubMed
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent
LigandPNGBDBM445677(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4TQ6US Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent
LigandPNGBDBM445677(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM2DRCUS Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent
LigandPNGBDBM357737(KM-05-166/(I-206) | US10214530, Example 24)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25B04SKUS Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent
LigandPNGBDBM357735(KM-05-193/(I-209) | US10214530, Example 27)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25B04SKUS Patent
TargetTryptophan 5-hydroxylase 2(Homo sapiens (Human))
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.

US Patent
LigandPNGBDBM357735(KM-05-193/(I-209) | US10214530, Example 27)copy SMILEScopy InChI
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164VFPubMed
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