Compile Data Set for Download or QSAR
Found 463 with Last Name = 'zamaratski' and Initial = 'e'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466897(CHEMBL4287715)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466891(CHEMBL4281109)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466893(CHEMBL4291727)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466892(CHEMBL4283871)copy SMILEScopy InChI
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466913(CHEMBL4289304)copy SMILEScopy InChI
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189904(US10227346, Example 29 | US10426135, Example 29 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189904(US10227346, Example 29 | US10426135, Example 29 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189904(US10227346, Example 29 | US10426135, Example 29 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411418(N-(3-((3R,4R)-1-((R)-2-cyclopentylpropanoyl)- 3-me...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411412((R)-2-fluoro-N-(1-methyl-3-(1-(2,3,3- trimethylbut...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411419(N-(3-((3R,4R)-1-((R)-2-cyclopentylpropanoyl)- 3-me...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411417(N-(3-((3R,4R)-1-((R)-2-cyclopentylpropanoyl)- 3-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM190325(US10227346, Example 81 | US10426135, Example 81 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM190325(US10227346, Example 81 | US10426135, Example 81 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM190325(US10227346, Example 81 | US10426135, Example 81 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411410((R)-1,3,5-trimethyl-N-(1-methyl-3-(1-(2,3,3- trime...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189884(US10227346, Example 11 | US10426135, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189884(US10227346, Example 11 | US10426135, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189884(US10227346, Example 11 | US10426135, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411411((R)-2-ethoxy-N-(1-methyl-3-(1-(2,3,3- trimethylbut...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM368656(3-cyano-N-(3-((1R,5S,8r)-3-isobutyryl-3- azabicycl...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM368656(3-cyano-N-(3-((1R,5S,8r)-3-isobutyryl-3- azabicycl...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM190322(US9670201, 78 3-cyano-N-(3-((1R,5S,8r)-3-isobutyry...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411409((R)-4-methyl-N-(1-methyl-3-(1-(2,3,3- trimethylbut...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411415((R)-N-(3-(1-(2-(bicyclo[1.1.1]pentan-1- yl)propano...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411416(N-(3-((3R,4R)-1-((R)-2-cyclopentylpropanoyl)- 3-me...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM190346(US10227346, Example 95 | US10426135, Example 95 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189895(US10227346, Example 22 | US10426135, Example 22 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM190346(US10227346, Example 95 | US10426135, Example 95 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189895(US10227346, Example 22 | US10426135, Example 22 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM190346(US10227346, Example 95 | US10426135, Example 95 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189895(US10227346, Example 22 | US10426135, Example 22 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189905(US10227346, Example 30 | US10426135, Example 30 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189905(US10227346, Example 30 | US10426135, Example 30 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189905(US10227346, Example 30 | US10426135, Example 30 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411400((S)-N-(3-(1-(2,3-dimethylbutanoyl)pipendin-4-yl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189874(US10227346, Example 3 | US10426135, Example 3 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189874(US10227346, Example 3 | US10426135, Example 3 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189874(US10227346, Example 3 | US10426135, Example 3 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466890(CHEMBL4290728)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189882(US10227346, Example 10 | US10426135, Example 10 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189882(US10227346, Example 10 | US10426135, Example 10 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189882(US10227346, Example 10 | US10426135, Example 10 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM411403((R)-N-(3-(1-(cyclopentanecarbonyl)-2,2-dimethylpip...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5B40US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189891(US10227346, Example 18 | US10426135, Example 18 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189891(US10227346, Example 18 | US10426135, Example 18 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189891(US10227346, Example 18 | US10426135, Example 18 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189888(US10227346, Example 15 | US10426135, Example 15 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189888(US10227346, Example 15 | US10426135, Example 15 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189888(US10227346, Example 15 | US10426135, Example 15 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
Displayed 1 to 50 (of 463 total ) | Next | Last >>
Jump to: