TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.180nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.190nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.320nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.550nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.570nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit gamma(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.700nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 1.70nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 2.21nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 3.64nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CDK6/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin) using retinoblastoma as substrate after 30 mins by autoradiography in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 4.01nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 4.66nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of ARK5 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin) using retinoblastoma as substrate after 30 mins by autoradiography in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 7.40nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 8nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of CDK6/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 12nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 15.6nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of His-6-tagged CDK2 (unknown origin) expressed in baculovirus-infected insect cells using histone H1 as substrate after 1 hr by by liquid...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 24.3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK1/cyclinB (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 37.3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 39.5nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of His-6-tagged CDK1 (unknown origin) expressed in baculovirus-infected insect cells using histone H1 as substrate after 1 hr by by liquid...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of CDK2/cyclinE (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 53nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 62.2nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 87.5nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 143nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 144nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 150nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 159nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK2/cyclinE (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 184nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of His-6-tagged CDK4 (unknown origin) expressed in baculovirus-infected insect cells using GST-retinoblastoma as substrate after 1 hr by b...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University School of Medicine
Curated by ChEMBL
Temple University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of BCR/ABL p210 autophosphorylation in human K562 cells after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 201nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetProtein kinase C zeta type(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 204nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 243nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant PLK2 using recombinant dephosphorylated bovine alpha- casein as substrate after 30 mins by scintillation counting ana...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant PLK2 using recombinant dephosphorylated bovine alpha- casein as substrate after 30 mins by scintillation counting ana...More data for this Ligand-Target Pair