Compile Data Set for Download or QSAR
Found 544 with Last Name = 'reddy' and Initial = 'ep'
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 0.190nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 0.550nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCalcium/calmodulin-dependent protein kinase type II subunit gamma(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 2.21nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447511(CHEMBL3115672)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 3.64nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CDK6/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin) using retinoblastoma as substrate after 30 mins by autoradiography in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 4.01nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 4.66nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of ARK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin) using retinoblastoma as substrate after 30 mins by autoradiography in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 7.40nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Inhibition of CDK6/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 15.6nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM7238((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of His-6-tagged CDK2 (unknown origin) expressed in baculovirus-infected insect cells using histone H1 as substrate after 1 hr by by liquid...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 24.3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK1/cyclinB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMedDrugBank
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 37.3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 39.5nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM7238((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of His-6-tagged CDK1 (unknown origin) expressed in baculovirus-infected insect cells using histone H1 as substrate after 1 hr by by liquid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of CDK2/cyclinE (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 62.2nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM6860(6-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:Inhibition of CDK4/cyclinD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 87.5nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM7585((R,S)-Roscovitine | 2,6,9-Trisubstituted purine de...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 143nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 144nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)copy SMILEScopy InChI
Affinity DataIC50: 159nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK2/cyclinE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 184nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM7238((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of His-6-tagged CDK4 (unknown origin) expressed in baculovirus-infected insect cells using GST-retinoblastoma as substrate after 1 hr by b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50326075((E)-4-(3-(4-Fluoro-3-nitrophenyl)-2-(4-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of BCR/ABL p210 autophosphorylation in human K562 cells after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z44N8PubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139539(US8889696, 39)copy SMILEScopy InChI
Affinity DataIC50: 201nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetProtein kinase C zeta type(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 204nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3FSWPubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)copy SMILEScopy InChI
Affinity DataIC50: 243nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2930RVRUS Patent
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM50135286(CHEMBL3745885)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant PLK2 using recombinant dephosphorylated bovine alpha- casein as substrate after 30 mins by scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7WT8PubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education

US Patent
LigandPNGBDBM50135424(CHEMBL3747595)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant PLK2 using recombinant dephosphorylated bovine alpha- casein as substrate after 30 mins by scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7WT8PubMed
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