TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2J966SRPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 5.54nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 5.93nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2J966SRPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 10.8nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 16.6nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 18.5nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 18.7nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 43.7nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of Erbb2 using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of EGFR autophosphorylation in EGF-stimulated human A431 cells after 1 hr by immunoblottingMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Antiproliferative activity against mouse 32Dcl3 cell line expressing wildtype FLT3More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Antiproliferative activity against mouse 32Dcl3 cell line expressing FLT3-ITDMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 171nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblastsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of endogenous FLT3 autophosphorylation in EOL1 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of EGFR autophosphorylation in EGF-stimulated human A431 cells after 1 hr by immunoblottingMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of Erbb2 using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of tubulin polymerization.More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of endogenous FLT3 autophosphorylation in EOL1 cellsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 458nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wildtype KITMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wildtype KITMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutantMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutantMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of tubulin polymerization.More data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of tubulin polymerization.More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 570nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 580nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Regensburg
Curated by ChEMBL
University of Regensburg
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of endogenous FLT3 autophosphorylation in EOL1 cellsMore data for this Ligand-Target Pair
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