Found 108 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM5445'
Affinity DataKi: 3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2ZG6WHWPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2ZG6WHWPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preinc...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2VQ368TPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2VQ368TPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as sub...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2VQ368TPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2VQ368TPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2R49V68PubMedDrugBank
MMDB
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3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2R49V68PubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2J38STXPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2J38STXPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 3nMpH: 7.5Assay Description:The EGFR, HER2 and HER4 kinase assay were performed using radiolabeled [gamma-32P] ATP from GE Healthcare. More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q27W69THPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q27W69THPubMedDrugBank
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PDB
3D Structure (crystal)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type EGFR (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2M90D7DPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2M90D7DPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 3.07nMAssay Description:EGFR: The compounds' inhibition of target modulation were determined as follows: NCI-H838 cells were sorted in 96 well plates (20000 cells/well) ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of EGFR (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2DZ0B04PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2DZ0B04PubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 7.60nMAssay Description:Assay Procedures:The abbreviations used in the following assay have the following meanings:HEPES: hydroxyethyl piperazine ethanesulfonic acid;Brij-35...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of HER1 (unknown origin) assessed as reduction in autophosphorylation by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q25B043MPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q25B043MPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 8nMAssay Description:Inhibition of wild-type EGFR expressed using baculovirus expression system by ELISAMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q21836ZVPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q21836ZVPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2M90D7DPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2M90D7DPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2J966SRPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 9nMAssay Description:Inhibition of human EGFR preincubated 2 hrs prior addition of ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2N29XCQPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2N29XCQPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 9nMAssay Description:Inhibition of EGFR after 50 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2DF6S7RPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2DF6S7RPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2HQ3X4MPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2HQ3X4MPubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2NV9JP4PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2NV9JP4PubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against metabotropic glutamate receptor 5 (mGluR5)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q27W6F0DPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q27W6F0DPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2JW8DH8PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2JW8DH8PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2VD6ZK0PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2VD6ZK0PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2RX9CCNPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2RX9CCNPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2NV9JP4PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2NV9JP4PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin) expressed in baculovirus system assessed as reduction in phosphorylation of Peptide A incubated for 10 mins by sc...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2474F5DPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2474F5DPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGF-induced EGFR phosphorylation at Tyr-residue in human HN5 cells preincubated for 24 hrs followed by EGF-stimulation and measured aft...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q28W3HK1PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q28W3HK1PubMedDrugBank
MMDB
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3D Structure (crystal)
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2G73JTWPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2G73JTWPubMedDrugBank
MMDB
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3D Structure (crystal)
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2PN99PGPubMedDrugBank
MMDB
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3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2PN99PGPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 10nMAssay Description:Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q27S7M35PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q27S7M35PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2JH3PWTPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2JH3PWTPubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin) after 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2DZ0B04PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2DZ0B04PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 11nMAssay Description:Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2JQ12TSPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2JQ12TSPubMedDrugBank
MMDB
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3D Structure (crystal)
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q28W3JD6PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q28W3JD6PubMedDrugBank
MMDB
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3D Structure (crystal)
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2TH8NNNPubMedDrugBank
MMDB
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3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2TH8NNNPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system after 1...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2NG4TZBPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2NG4TZBPubMedDrugBank
MMDB
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3D Structure (crystal)
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2CR5TGQPubMedDrugBank
MMDB
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3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2CR5TGQPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin) expressed in baculovirus expression system using Biotin-(amino hexonoic acid)-EEEEYFELVAKKKCONH2 as substrate and...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q22N548XPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q22N548XPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q27D2XS5PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q27D2XS5PubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q21J9FHZPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q21J9FHZPubMedDrugBank
MMDB
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3D Structure (crystal)
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2VM4D2ZPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2VM4D2ZPubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 13nMAssay Description:Inhibition of exogenous EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2T43XZ9PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2T43XZ9PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 15nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2930XXQPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2930XXQPubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 16nMAssay Description:Samples:Controls: Gefitinib, erlotinib hydrochloride, purchased from Anqing worldchem Co., LTD.; lapatinib ditosylate, purchased from Taizhou Xingche...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of EGFR (unknown origin) using poly-(Glu4-Tyr) as substrate after 1 hr by ELISA-based spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2GT5R41PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2GT5R41PubMedDrugBank
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3D Structure (crystal)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q27W6C7QPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q27W6C7QPubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 19nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q25B02K2PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q25B02K2PubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 21nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMedDrugBank
MMDB
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3D Structure (crystal)
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2G44TV0PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2G44TV0PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
Affinity DataIC50: 24nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R/T790M mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK ...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2VQ368TPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2VQ368TPubMedDrugBank
MMDB
PDB
3D Structure (crystal)