Compile Data Set for Download or QSAR
Found 199 with Last Name = 'kelleher' and Initial = 'jf'
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50277189((R)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50107789((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269112(1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268313(2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50107786((R)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277330((S)-6-methyl-N-(2-((4-methylthiazol-2-yl)methylami...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50107813((S)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268313(2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269112(1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277332((S)-6-methyl-N-(2-((5-methylfuran-2-yl)methylamino...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50277297((S)-6-methyl-N-(2-(thiophen-2-ylmethylamino)-2,3-d...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50277330((S)-6-methyl-N-(2-((4-methylthiazol-2-yl)methylami...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277258((S)-N-(2-(benzylamino)-2,3-dihydro-1H-inden-5-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50268313(2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277297((S)-6-methyl-N-(2-(thiophen-2-ylmethylamino)-2,3-d...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50277332((S)-6-methyl-N-(2-((5-methylfuran-2-yl)methylamino...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268314(1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277190((S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277298((S)-N-(2-(furan-2-ylmethylamino)-2,3-dihydro-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50277258((S)-N-(2-(benzylamino)-2,3-dihydro-1H-inden-5-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269085(CHEMBL495877 | {6-[4-(4-Benzylphthalazin-1-yl)pipe...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50269112(1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268610(6-[(R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperaz...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50268612(6-[(S)-4-(4-Benzylphthalazin-1-yl)-3-methylpiperaz...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268315((+/-)-2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268494(6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268495(6-{4-[4-(4-Cyanobenzyl)phthalazin-1-yl]piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50268314(1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268612(6-[(S)-4-(4-Benzylphthalazin-1-yl)-3-methylpiperaz...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268495(6-{4-[4-(4-Cyanobenzyl)phthalazin-1-yl]piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268612(6-[(S)-4-(4-Benzylphthalazin-1-yl)-3-methylpiperaz...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50268494(6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268315((+/-)-2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277293(6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50277190((S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268610(6-[(R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperaz...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50277293(6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50268495(6-{4-[4-(4-Cyanobenzyl)phthalazin-1-yl]piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50268610(6-[(R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperaz...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268313(2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 25 nM 3-chloro-4,7-difluo...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269111(CHEMBL523255 | N-{6-[4-(4-Benzylphthalazin-1-yl)pi...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268312(1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269112(1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 25 nM 3-chloro-4,7-difluo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269083(6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicot...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268494(6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268493(6-{4-[4-(3-Chlorobenzyl)phthalazin-1-yl]piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50277294(6-methyl-N-((2S)-2-(2,2,2-trifluoro-1-phenylethyla...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268314(1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]py...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277294(6-methyl-N-((2S)-2-(2,2,2-trifluoro-1-phenylethyla...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50107787((S)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
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