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Found 1175 with Last Name = 'hyatt' and Initial = 'jl'
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350329(CHEMBL1812859)copy SMILEScopy InChI
Affinity DataKi:  0.840nMAssay Description:Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22859(1,2-Dione-Based Compound, 16 | 1,2-dihydroaceanthr...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350326(CHEMBL1812864)copy SMILEScopy InChI
Affinity DataKi:  2.19nMAssay Description:Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22857(1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22857(1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0HWJPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350321(CHEMBL1812856)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22741(1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione | ...)copy SMILEScopy InChI
Affinity DataKi:  4.10nM ΔG°:  -47.9kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM22733(1,2-bis(4-bromophenyl)ethane-1,2-dione | Benzil-ba...)copy SMILEScopy InChI
Affinity DataKi:  4.10nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50233201(CHEMBL4101254)copy SMILEScopy InChI
Affinity DataKi:  4.40nMAssay Description:Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VMPPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50233200(CHEMBL4071772)copy SMILEScopy InChI
Affinity DataKi:  4.70nMAssay Description:Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VMPPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350327(CHEMBL1812857)copy SMILEScopy InChI
Affinity DataKi:  4.80nMAssay Description:Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350327(CHEMBL1812857)copy SMILEScopy InChI
Affinity DataKi:  4.80nMAssay Description:Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0HWJPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50233189(CHEMBL4090451)copy SMILEScopy InChI
Affinity DataKi:  4.90nMAssay Description:Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VMPPubMed
TargetCocaine esterase(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50209402(1,2-bis(2,3-fluorophenyl)ethane-1,2-dione | CHEMBL...)copy SMILEScopy InChI
Affinity DataKi:  4.98nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5MGVPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22850(1,2-Dione-Based Compound, 7 | 1,2-dicyclohexyletha...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22850(1,2-Dione-Based Compound, 7 | 1,2-dicyclohexyletha...)copy SMILEScopy InChI
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  5.60nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  5.60nM ΔG°:  -47.1kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetCocaine esterase(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350329(CHEMBL1812859)copy SMILEScopy InChI
Affinity DataKi:  5.70nMAssay Description:Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM22845(1-{[4-({4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)me...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3CNKPubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  6.10nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM50350328(CHEMBL1812858)copy SMILEScopy InChI
Affinity DataKi:  6.5nMAssay Description:Inhibition of rabbit liver carboxylesterase using o-nitrophenyl acetate as substrate after for 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350325(CHEMBL1812863)copy SMILEScopy InChI
Affinity DataKi:  6.65nMAssay Description:Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350325(CHEMBL1812863)copy SMILEScopy InChI
Affinity DataKi:  6.70nMAssay Description:Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0HWJPubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)copy SMILEScopy InChI
Affinity DataKi:  6.90nM ΔG°:  -46.1kJ/molepH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350328(CHEMBL1812858)copy SMILEScopy InChI
Affinity DataKi:  7.60nMAssay Description:Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0HWJPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50350328(CHEMBL1812858)copy SMILEScopy InChI
Affinity DataKi:  7.60nMAssay Description:Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22859(1,2-Dione-Based Compound, 16 | 1,2-dihydroaceanthr...)copy SMILEScopy InChI
Affinity DataKi:  7.70nM ΔG°:  -46.3kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22748(1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dion...)copy SMILEScopy InChI
Affinity DataKi:  7.90nM ΔG°:  -46.2kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22845(1-{[4-({4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)me...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3CNKPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22842(1-dodecyl-2,3-dihydro-1H-indole-2,3-dione | CHEMBL...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3CNKPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM22747(1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione | B...)copy SMILEScopy InChI
Affinity DataKi:  8.70nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22745(1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1...)copy SMILEScopy InChI
Affinity DataKi:  8.90nM ΔG°:  -46.0kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM50350329(CHEMBL1812859)copy SMILEScopy InChI
Affinity DataKi:  9nMAssay Description:Inhibition of rabbit liver carboxylesterase using o-nitrophenyl acetate as substrate after for 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7WB9PubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM22731(1,2-bis(4-chlorophenyl)ethane-1,2-dione | Benzil-b...)copy SMILEScopy InChI
Affinity DataKi:  9.5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22845(1-{[4-({4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)me...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3CNKPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22842(1-dodecyl-2,3-dihydro-1H-indole-2,3-dione | CHEMBL...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3CNKPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22742(1-(4-methoxyphenyl)-2-phenylethane-1,2-dione | Ben...)copy SMILEScopy InChI
Affinity DataKi:  10.3nM ΔG°:  -45.6kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50233189(CHEMBL4090451)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interval for...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VMPPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22843(1-hexadecyl-2,3-dihydro-1H-indole-2,3-dione | Isat...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3CNKPubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM22748(1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dion...)copy SMILEScopy InChI
Affinity DataKi:  11.9nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50233194(CHEMBL4087100)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VMPPubMed
TargetCocaine esterase(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50209418(1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione | C...)copy SMILEScopy InChI
Affinity DataKi:  13.6nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5MGVPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM50233199(CHEMBL4098780)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VMPPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Benzil | CHEMBL1898...)copy SMILEScopy InChI
Affinity DataKi:  14.7nM ΔG°:  -44.7kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Benzil | CHEMBL1898...)copy SMILEScopy InChI
Affinity DataKi:  14.7nM ΔG°:  -44.7kJ/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetCocaine esterase(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Benzil | CHEMBL1898...)copy SMILEScopy InChI
Affinity DataKi:  14.7nMAssay Description:Inhibition constant against human intestinal carboxylesterase (hiCE) expressed in Sf21 cells using 3 mM o-NPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB52G3PubMed
TargetCocaine esterase(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Benzil | CHEMBL1898...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0HWJPubMed
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