Compile Data Set for Download or QSAR
Found 240 with Last Name = 'hashimoto' and Initial = 'm'
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of human PNP in presence of 0.025 mM phosphateMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.02...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of calf PNP in presence of 0.025 mM phosphateMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.025 mM i...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.025 mM i...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)copy SMILEScopy InChI
Affinity DataKi:  2.70nMAssay Description:Inhibition of calf PNP in presence of 0.025 mM phosphateMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)copy SMILEScopy InChI
Affinity DataKi:  4.40nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)copy SMILEScopy InChI
Affinity DataKi:  5.30nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MG0PubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50415479(CHEMBL601619)copy SMILEScopy InChI
Affinity DataKi:  5.60nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MG0PubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214708(6-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyri...)copy SMILEScopy InChI
Affinity DataKi:  5.70nMAssay Description:Inhibition of calf PNP in presence of 1 mM phosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P31CSPubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)copy SMILEScopy InChI
Affinity DataKi:  5.70nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MG0PubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50415479(CHEMBL601619)copy SMILEScopy InChI
Affinity DataKi:  6.10nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MG0PubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50415479(CHEMBL601619)copy SMILEScopy InChI
Affinity DataKi:  6.10nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MG0PubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)copy SMILEScopy InChI
Affinity DataKi:  6.90nMAssay Description:Inhibition of bovine PNP using 7-methylguanosine as substrate by spectrophotometric based coupled assayMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)copy SMILEScopy InChI
Affinity DataKi:  6.90nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrofluorimetric method in presence of 1...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)copy SMILEScopy InChI
Affinity DataKi:  8.10nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)copy SMILEScopy InChI
Affinity DataKi:  10.8nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MG0PubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MG0PubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)copy SMILEScopy InChI
Affinity DataKi:  41nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 50 mM inor...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50394443(CHEMBL2159650)copy SMILEScopy InChI
Affinity DataKi:  63nMAssay Description:Inhibition of bovine PNP using 7-methylguanosine as substrate by spectrophotometric based coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24H7PubMed
TargetProthrombin(Bos taurus (Bovine))
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50322033(2-Methylisoindole-1,3-dione-5-yl 3-(6-aminopyridin...)copy SMILEScopy InChI
Affinity DataKi:  7.00E+3nMAssay Description:Binding affinity to bovine thrombin after 3 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0394ZPubMed
TargetProthrombin(Bos taurus (Bovine))
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50322034(2-(4-Cyanophenyl)isoindole-1,3-dione-5-yl(E)-3-(4-...)copy SMILEScopy InChI
Affinity DataKi:  8.60E+3nMAssay Description:Binding affinity to bovine thrombin after 3 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0394ZPubMed
TargetProthrombin(Bos taurus (Bovine))
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50322032(2-Methylisoindole-1,3-dione-5-yl 3-(4-aminophenyl)...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to bovine thrombin after 3 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0394ZPubMed
TargetProthrombin(Bos taurus (Bovine))
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50322035(2-(4-cyanophenyl)isoindole-1,3-dione-5-yl 3-(2-ami...)copy SMILEScopy InChI
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity to bovine thrombin after 3 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0394ZPubMed
TargetEndoglucanase-5(Humicola insolens)
Hirosaki University

Curated by ChEMBL
LigandPNGBDBM50346888(CHEMBL1797815)copy SMILEScopy InChI
Affinity DataKi:  4.20E+5nMpH: 4.0Assay Description:Binding affinity to Humicola insolens NCE5 assessed as dissociation constant at pH 4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057G8CPubMed
TargetEndoglucanase-5(Humicola insolens)
Hirosaki University

Curated by ChEMBL
LigandPNGBDBM50346887(CHEMBL1797814)copy SMILEScopy InChI
Affinity DataKi:  1.60E+6nMpH: 3.0Assay Description:Binding affinity to Humicola insolens NCE5 assessed as dissociation constant at pH 3.0 and at 59 degC by differential scanning calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057G8CPubMed
TargetEndoglucanase-5(Humicola insolens)
Hirosaki University

Curated by ChEMBL
LigandPNGBDBM50346884(CHEMBL1797811)copy SMILEScopy InChI
Affinity DataKi:  3.90E+6nMpH: 3.0Assay Description:Binding affinity to Humicola insolens NCE5 assessed as dissociation constant at pH 3.0 and at 59 degC by differential scanning calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057G8CPubMed
TargetEndoglucanase-5(Humicola insolens)
Hirosaki University

Curated by ChEMBL
LigandPNGBDBM50346885(CHEMBL1797812)copy SMILEScopy InChI
Affinity DataKi:  2.50E+7nMpH: 3.0Assay Description:Binding affinity to Humicola insolens NCE5 assessed as dissociation constant at pH 3.0 and at 59 degC by differential scanning calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057G8CPubMed
TargetEndoglucanase-5(Humicola insolens)
Hirosaki University

Curated by ChEMBL
LigandPNGBDBM50346886(CHEMBL1797813)copy SMILEScopy InChI
Affinity DataKi:  2.90E+7nMpH: 3.0Assay Description:Binding affinity to Humicola insolens NCE5 assessed as dissociation constant at pH 3.0 and at 59 degC by differential scanning calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057G8CPubMed
TargetEndoglucanase-5(Humicola insolens)
Hirosaki University

Curated by ChEMBL
LigandPNGBDBM50346883(CHEMBL1797810)copy SMILEScopy InChI
Affinity DataKi: >3.00E+7nMpH: 3.0Assay Description:Binding affinity to Humicola insolens NCE5 assessed as dissociation constant at pH 3.0 and at 59 degC by differential scanning calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057G8CPubMed
TargetEndoglucanase-5(Humicola insolens)
Hirosaki University

Curated by ChEMBL
LigandPNGBDBM50346882(CHEMBL1797809)copy SMILEScopy InChI
Affinity DataKi: >3.00E+7nMpH: 3.0Assay Description:Binding affinity to Humicola insolens NCE5 assessed as dissociation constant at pH 3.0 and at 59 degC by differential scanning calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057G8CPubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)copy SMILEScopy InChI
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542NDJPubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)copy SMILEScopy InChI
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2Q57PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)copy SMILEScopy InChI
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542NDJPubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542NDJPubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542NDJPubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2Q57PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50373360(CHEMBL263917)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2Q57PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50373360(CHEMBL263917)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2Q57PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293856(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-{[1S,3R,6S)-2,1...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98835PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50373365(CHEMBL258710)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2Q57PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542NDJPubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293855(4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98835PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98835PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50293857(1-(1,3-dihydroxypropan-2-yl)-3-(1-((1R,3S,4S)-spir...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98835PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50373362(CHEMBL263919)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2Q57PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542NDJPubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50368147((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoAMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239745(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542NDJPubMed
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