Affinity DataKi: 1.40nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
Affinity DataKi: 6.10nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
Affinity DataKi: 62nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMpH: 7.2 T: 2°CAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of AKT2 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q27D2XS5PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q27D2XS5PubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 11.4nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of AKT3 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer Global Research and Development
Curated by ChEMBL
Pfizer Global Research and Development
Curated by ChEMBL
Affinity DataIC50: 17.5nMAssay Description:Inhibition of AKT1 after 90 mins by IMAP assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Central Research
Curated by ChEMBL
Pfizer Central Research
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q27D2XS5PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q27D2XS5PubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMpH: 7.2 T: 2°CAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
![](/img/powered_by_small.gif)