Compile Data Set for Download or QSAR
Found 439 with Last Name = 'waldbrook' and Initial = 'm'
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Xenon Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50169425(CHEMBL3341983 | US9481677, 44)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Nav1.7 channel in mouse CAD cells by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50118514(CHEMBL3617063 | US9481677, 38)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145281(US8952169, 60 | US9771376, Example 60)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50118514(CHEMBL3617063 | US9481677, 38)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50118514(CHEMBL3617063 | US9481677, 38)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169425(CHEMBL3341983 | US9481677, 44)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169425(CHEMBL3341983 | US9481677, 44)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full length human Nav1.7 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169426(CHEMBL3806065 | US9481677, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length human Nav1.7 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM71064(US9546164, 209 | US9694002, 209)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50118514(CHEMBL3617063 | US9481677, 38)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM268527(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7K92PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145369(US8952169, 148 | US9771376, Example 148)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145281(US8952169, 60 | US9771376, Example 60)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169434(CHEMBL3805837 | US9481677, 80)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169431(CHEMBL3805722 | US9481677, 73)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169432(CHEMBL3805973 | US9481677, 48)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM70936(US9546164, 99 | US9694002, 99)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM268527(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of inactivated state of recombinant wild type human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7K92PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM145591(US8952169, 389)copy SMILEScopy InChI
In DepthDetails
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50465470(CHEMBL4277472)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7K92PubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Xenon Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM145591(US8952169, 389)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145375(US8952169, 154)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145376(US8952169, 155)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM70987(US9546164, 139 | US9694002, 139)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Xenon Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM145466(US8952169, 245)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)copy SMILEScopy InChI
In DepthDetails
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM268418(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7K92PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169433(CHEMBL3805201 | US9481677, 58)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM268423(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7K92PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145374(US8952169, 153)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50587016(CHEMBL5091342)copy SMILES
Affinity DataIC50: 3.60nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169430(CHEMBL3805347 | US9481677, 59)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
LigandPNGBDBM145591(US8952169, 389)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50587015(CHEMBL5082739)copy SMILES
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of inactivated state of recombinant wild type human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as d...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7K92PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50169425(CHEMBL3341983 | US9481677, 44)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169438(CHEMBL3804898 | US9481677, 63)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50615672(CHEMBL5272143)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Xenon Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM268527(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of inactivated state of mouse NaV1.7 assessed as decrease in sodium current amplitude at -60 mV holding potential after 20 mins by Qube384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7K92PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50169427(CHEMBL3805897 | US9481677, 45)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145635(US8952169, 440)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145382(US8952169, 161)copy SMILEScopy InChI
In DepthDetails
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145266(US8952169, 45)copy SMILEScopy InChI
In DepthDetails
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