Compile Data Set for Download or QSAR
Found 31 with Last Name = 'garstka' and Initial = 'ma'
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)copy SMILEScopy InChI
Affinity DataKi:  220nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)copy SMILEScopy InChI
Affinity DataKi:  330nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaMore data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50391236(CHEMBL5276748)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50391229(CHEMBL5285501)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM12577(Bisphosphonate 2 | CHEMBL997 | JMC515594 Compound ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaMore data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50391230(CHEMBL5276276)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50391233(CHEMBL5082037)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50382684(CHEMBL2023158 | US9409868, 24)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCell division control protein 42 homolog(Homo sapiens (Human))TBA
LigandPNGBDBM50391237(CHEMBL5290216)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM36511(5-((2-Carboxy-1H-benzo[g]indol-1-yl)methyl)isoxazo...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atriaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50391232(CHEMBL5275415)copy SMILEScopy InChI
Affinity DataIC50: 82nMAssay Description:Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50391237(CHEMBL5290216)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50382684(CHEMBL2023158 | US9409868, 24)copy SMILEScopy InChI
Affinity DataIC50: 122nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50391231(CHEMBL5272025)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50391234(CHEMBL5282126)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM25313((4-amino-1-hydroxy-1-phosphonobutyl)phosphonic aci...)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaMore data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))TBA
LigandPNGBDBM12581((3-amino-1-hydroxy-1-phosphonopropyl)phosphonic ac...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaMore data for this Ligand-Target Pair
LigandPNGBDBM50391242(CHEMBL5276821)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50391241(CHEMBL1221574)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)copy SMILEScopy InChI
Affinity DataIC50: 4.58E+3nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50391235(CHEMBL3216441)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)copy SMILEScopy InChI
Affinity DataIC50: 1.23E+4nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50468262(CHEMBL4277903)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+4nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50391238(CHEMBL5277596)copy SMILEScopy InChI
Affinity DataEC50:  8.30E+3nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50391239(CHEMBL1404260)copy SMILEScopy InChI
Affinity DataEC50:  2.24E+4nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50391240(CHEBI:76228 | CHEMBL496240)copy SMILEScopy InChI
Affinity DataEC50:  574nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCell division control protein 42 homolog(Homo sapiens (Human))TBA
LigandPNGBDBM50391240(CHEBI:76228 | CHEMBL496240)copy SMILEScopy InChI
Affinity DataEC50:  1.07E+3nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails Article