Compile Data Set for Download or QSAR
Found 319 with Last Name = 'hirth' and Initial = 'p'
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM3531(CHEMBL541586 | CHEMBL94431 | N-(3-fluorophenyl)-6,...)copy SMILEScopy InChI
Affinity DataIC50: 90nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065303(3-[1-(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 160nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065283(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4403(3-[(6-methylquinazolin-4-yl)amino]benzamide | 4-An...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065292((Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-met...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM17015((3Z)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM4882((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4398(4-Anilidoquinazoline deriv. 13a | N-(3-chloropheny...)copy SMILEScopy InChI
Affinity DataIC50: 600nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)copy SMILEScopy InChI
Affinity DataIC50: 900nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM3533(CHEMBL1204305 | CHEMBL96065 | N-(3-iodophenyl)-6,7...)copy SMILEScopy InChI
Affinity DataIC50: 950nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065288(3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4404(3-[(6-methylquinazolin-4-yl)amino]benzoic acid | 4...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065306(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4399(4-Anilidoquinazoline deriv. 14a | N-(3-bromophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMpH: 7.5 T: 2°CAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065312((Z)-4-methyl-3-(4-morpholinobenzylidene)indolin-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4400(4-Anilidoquinazoline deriv. 15b | 6-methyl-N-[3-(t...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMpH: 7.5 T: 2°CAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065273(3-[1-(5-Methylsulfanyl-thiophen-2-yl)-meth-(Z)-yli...)copy SMILEScopy InChI
Affinity DataIC50: 2.34E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065280(3-[1-(4-Morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065290((Z)-4-(4-((4-methyl-2-oxoindolin-3-ylidene)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065311(3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-yliden...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065304(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4397(4-Anilidoquinazoline deriv. 12a | 6-chloro-N-(3-ch...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065302(6-Fluoro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4420(2-chloro-N-(3-chlorophenyl)-6,7-dimethoxyquinazoli...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065317(5-Chloro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-i...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065314(3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065294(3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihyd...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065295(3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetAurora kinase A(Homo sapiens (Human))
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB441TPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM4395(4-Anilidoquinazoline deriv. 10a | N-(3,5-dichlorop...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065277(5-Chloro-3-(4-morpholin-4-yl-benzylidene)-1,3-dihy...)copy SMILEScopy InChI
Affinity DataIC50: 4.10E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University of Jerusalem

LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)copy SMILEScopy InChI
Affinity DataIC50: 4.16E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC3WR8PubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065307(5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065276(3-[1-(4-Piperidin-1-yl-phenyl)-meth-(Z)-ylidene]-1...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
SUGEN, Inc.

Curated by ChEMBL
LigandPNGBDBM50065298(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73CTTPubMed
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