TargetSolute carrier family 15 member 1(Homo sapiens (Human))
Dalian Medical University
Curated by ChEMBL
Dalian Medical University
Curated by ChEMBL
Affinity DataKi: 2.50E+6nMAssay Description:Substrate activity at PEPT1 in human Caco2 cells assessed as inhibition of Gly-Sar uptake by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSolute carrier family 15 member 1(Homo sapiens (Human))
Dalian Medical University
Curated by ChEMBL
Dalian Medical University
Curated by ChEMBL
Affinity DataKi: 3.60E+7nMAssay Description:Substrate activity at PEPT1 in human Caco2 cells assessed as inhibition of Gly-Sar uptake by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of full length GST-tagged human CDK2/Cyclin AMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant GST-tagged human CDK1/cyclin B expressed in SF-9 cells after 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/cyclin E expressed in SF-9 cells after 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of full length GST-tagged human CDK1/cyclin BMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human CDK2/cyclin E after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human CDK2/cyclin A after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant human CDK9/cyclin T after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of CDK13 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human CDK5/p25 after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 19(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 127nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 12(Homo sapiens)
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 158nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 163nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 163nMAssay Description:Inhibition of recombinant human HDAC1 using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 181nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 185nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2C53QDZPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2C53QDZPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 224nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 235nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 274nMAssay Description:Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins...More data for this Ligand-Target Pair
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