TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2DV1KBVPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2DV1KBVPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLKMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLKMore data for this Ligand-Target Pair
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