Compile Data Set for Download or QSAR
Found 133 with Last Name = 'troxler' and Initial = 'tj'
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159251(US9034874, 2.2)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159252(US9034874, 2.3)copy SMILEScopy InChI
Affinity DataKi:  0.900nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159248(US9034874, 1.5)copy SMILEScopy InChI
Affinity DataKi:  1.10nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159253(US9034874, 3.1)copy SMILEScopy InChI
Affinity DataKi:  1.20nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159246(US9034874, 1.3)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159244(US9034874, 1.1)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159253(US9034874, 3.1)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159247(US9034874, 1.4)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159245(US9034874, 1.2)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159249(US9034874, 1.6)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159250(US9034874, 2.1)copy SMILEScopy InChI
Affinity DataKi:  3.10nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159246(US9034874, 1.3)copy SMILEScopy InChI
Affinity DataKi:  10nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159252(US9034874, 2.3)copy SMILEScopy InChI
Affinity DataKi:  12nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159250(US9034874, 2.1)copy SMILEScopy InChI
Affinity DataKi:  20nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159247(US9034874, 1.4)copy SMILEScopy InChI
Affinity DataKi:  25nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159248(US9034874, 1.5)copy SMILEScopy InChI
Affinity DataKi:  25nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159251(US9034874, 2.2)copy SMILEScopy InChI
Affinity DataKi:  25nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159244(US9034874, 1.1)copy SMILEScopy InChI
Affinity DataKi:  26nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159245(US9034874, 1.2)copy SMILEScopy InChI
Affinity DataKi:  31nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM159249(US9034874, 1.6)copy SMILEScopy InChI
Affinity DataKi:  44nMpH: 7.5Assay Description:The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-alpha -M...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C82819US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239101(US10195181, Example 2.2 | US9403810, 2.2)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239101(US10195181, Example 2.2 | US9403810, 2.2)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239117(US10195181, Example 22c | US9403810, 22)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239132(US9403810, 22c)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239094(US10195181, Example 1.3 | US9403810, 1.3)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239094(US10195181, Example 1.3 | US9403810, 1.3)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239092(US10195181, Example 1.1 | US9403810, 1.1)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239092(US10195181, Example 1.1 | US9403810, 1.1)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239099(US10195181, Example 2 | US9403810, 2)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239099(US10195181, Example 2 | US9403810, 2)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239091(US10195181, Example 1 | US9403810, 1)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239091(US10195181, Example 1 | US9403810, 1)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239095(US10195181, Example 1.4 | US9403810, 1.4)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239095(US10195181, Example 1.4 | US9403810, 1.4)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239105(US10195181, Example 6 | US9403810, 6)copy SMILEScopy InChI
Affinity DataIC50: 5.70nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239105(US10195181, Example 6 | US9403810, 6)copy SMILEScopy InChI
Affinity DataIC50: 5.70nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239096(US10195181, Example 1.5 | US9403810, 1.5)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239096(US10195181, Example 1.5 | US9403810, 1.5)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239102(US10195181, Example 3 | US9403810, 3)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239102(US10195181, Example 3 | US9403810, 3)copy SMILEScopy InChI
Affinity DataIC50: 6nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239097(US10195181, Example 1.6 | US9403810, 1.6)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239097(US10195181, Example 1.6 | US9403810, 1.6)copy SMILEScopy InChI
Affinity DataIC50: 8nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239093(US10195181, Example 1.2 | US9403810, 1.2)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239093(US10195181, Example 1.2 | US9403810, 1.2)copy SMILEScopy InChI
Affinity DataIC50: 14nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239107(US10195181, Example 7 | US9403810, 7)copy SMILEScopy InChI
Affinity DataIC50: 19nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239107(US10195181, Example 7 | US9403810, 7)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239106(US10195181, Example 6.1 | US9403810, 6.1)copy SMILEScopy InChI
Affinity DataIC50: 23nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239106(US10195181, Example 6.1 | US9403810, 6.1)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239098(US10195181, Example 1.7 | US9403810, 1.7)copy SMILEScopy InChI
Affinity DataIC50: 33nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2F1FUS Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239098(US10195181, Example 1.7 | US9403810, 1.7)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
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