Compile Data Set for Download or QSAR
Found 448 with Last Name = 'chen' and Initial = 'zs'
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Kagoshima University

Curated by ChEMBL
LigandPNGBDBM50420182(CHEMBL2074650)copy SMILEScopy InChI
Affinity DataKi:  3.70E+3nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RJ4KQXPubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Kagoshima University

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)copy SMILEScopy InChI
Affinity DataKi:  4.70E+3nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RJ4KQXPubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Kagoshima University

Curated by ChEMBL
LigandPNGBDBM50001285((E)-3-((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)(...)copy SMILEScopy InChI
Affinity DataKi:  1.31E+4nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RJ4KQXPubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Kagoshima University

Curated by ChEMBL
LigandPNGBDBM50390978(VALSPODAR)copy SMILEScopy InChI
Affinity DataKi:  2.89E+4nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RJ4KQXPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50579388(CHEMBL4877510)copy SMILES
Affinity DataIC50: 1.30nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50RSGPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50259682(CHEMBL4082527)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50356877(CHEMBL1614710)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445MW7PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50259682(CHEMBL4082527)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50259682(CHEMBL4082527)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of CYP3A4 in in human liver microsomes at incubated for 10 mins in presence of CYP3A4 substrate/NADP+ by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human CYP3A4 preincubated for 10 mins followed by substrate and NADP addition measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027P1PubMedDrugBank
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR exon 19 deletion mutant (unknown origin)More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50259682(CHEMBL4082527)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50259682(CHEMBL4082527)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 26nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22V2M59PubMedDrugBank
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50356877(CHEMBL1614710)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445MW7PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50450079(CHEMBL4166976)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K93B3MPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 35nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22V2M59PubMedDrugBank
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50450079(CHEMBL4166976)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K93B3MPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP3A4 (unknown origin) expressed in baculosomesMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50259681(CHEMBL4072052)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50450079(CHEMBL4166976)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K93B3MPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant human CYP3A4 in presence of NADPH generating system by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1851NPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))TBA
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 66nMMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant CYP3A4 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50RSGPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50247405(CHEMBL4077753)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Displacement of [125I]-IAAP from human P-gp expressed in high five insect cell membrane vesicles preincubated for 10 mins followed by photocrosslinki...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20R9RVXPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50451288(CHEMBL4212450)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z183XPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, United States.

Curated by ChEMBL
LigandPNGBDBM50261744(CHEMBL4096318)copy SMILEScopy InChI
Affinity DataIC50: 131nMAssay Description:Inhibition of ABCG2 in human H460/MX20 cells assessed as potentiation of mitoxantrone induced antiproliferative activity by measuring mitoxantrone IC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7JQ1PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, United States.

Curated by ChEMBL
LigandPNGBDBM50261744(CHEMBL4096318)copy SMILEScopy InChI
Affinity DataIC50: 131nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7JQ1PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 188nMMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50451288(CHEMBL4212450)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z183XPubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, United States.

Curated by ChEMBL
LigandPNGBDBM50261744(CHEMBL4096318)copy SMILEScopy InChI
Affinity DataIC50: 207nMAssay Description:Inhibition of ABCG2 in human H460/MX20 cells assessed as potentiation of mitoxantrone induced antiproliferative activity by measuring mitoxantrone IC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7JQ1PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50549433(CHEMBL4795035)copy SMILES
Affinity DataIC50: 220nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50451307(CHEMBL4203110)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z183XPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))TBA
LigandPNGBDBM50259686(CHEMBL4060820)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K2D5FPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
St. John's University

Curated by ChEMBL
LigandPNGBDBM50451309(CHEMBL4215496)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z183XPubMed
Displayed 1 to 50 (of 448 total ) | Next | Last >>
Jump to: