Compile Data Set for Download or QSAR
Found 163 Enz. Inhib. hit(s) with Target = 'Aldo-keto reductase family 1 member A1'
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)copy SMILEScopy InChI
Affinity DataIC50: 0.480nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50038843((4R)-2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'...)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reductionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35TTHPubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50009844(2-fluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H-imi...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibitory activity was measured against renal inner medulla aldehyde reductaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0KN9PubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50038843((4R)-2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of pig ALR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z734ZPubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50330615(4-Amino-N-(4-bromo-2-fluorobenzyl)-N-(3,5-difluoro...)copy SMILEScopy InChI
Affinity DataIC50: 323nMAssay Description:Inhibition of Fischer-344 rat kidney AK1A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2WRMPubMed
TargetAldo-keto reductase family 1 member A1(Bos taurus (Cattle))
COMSATS Institute of Information Technology

LigandPNGBDBM193860((E)-3-(2-(2-((2-amino-4-chlorophenyl)(phenyl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 459nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445K96PubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50126777(CHEMBL33835 | Cyano-[5-fluoro-1-(4-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0KN9PubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMedDrugBank
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50126780(CHEMBL30993 | Cyano-[5-fluoro-1-(4-methyl-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 690nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0KN9PubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 720nMAssay Description:Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reductionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35TTHPubMed
TargetAldo-keto reductase family 1 member A1(Bos taurus (Cattle))
COMSATS Institute of Information Technology

LigandPNGBDBM193856((E)-3-(2-(2-(1-(3-fluoro-4-methoxyphenyl)ethyliden...)copy SMILEScopy InChI
Affinity DataIC50: 1.08E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445K96PubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Tested for in vitro inhibition activity against human aldehyde reductase (AHR)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.21E+3nMAssay Description:Evaluated for inhibition of Aldehyde reductase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58N21PubMed
TargetAldo-keto reductase family 1 member A1(Bos taurus (Cattle))
COMSATS Institute of Information Technology

LigandPNGBDBM193858((E)-3-(2-(2-(1-(4-hydroxy-3-methoxyphenyl)ethylide...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445K96PubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50241817(CHEMBL4081954)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human AKR1A1 using pyridine-3-aldehyde as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ89S7PubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibitory activity against rat kidney aldehyde reductase(ALR).More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251H84PubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50241828(CHEMBL4089817)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human AKR1A1 using pyridine-3-aldehyde as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ89S7PubMed
TargetAldo-keto reductase family 1 member A1(Bos taurus (Cattle))
COMSATS Institute of Information Technology

LigandPNGBDBM193852((E)-3-(2-(2-(1-(4-bromophenyl)ethylidene)hydraziny...)copy SMILEScopy InChI
Affinity DataIC50: 1.71E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445K96PubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)copy SMILEScopy InChI
Affinity DataIC50: 1.74E+3nMAssay Description:Evaluated for inhibition of Aldehyde reductase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58N21PubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory activity measured against pig kidney aldehyde reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.94E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16462(2-{3-[(6-chloro-1,3-benzothiazol-2-yl)methyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of pig ALR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z734ZPubMedDrugBank
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)copy SMILEScopy InChI
Affinity DataIC50: 2.32E+3nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0KN9PubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human recombinant AKR1A1 expressed in Escherichia coli BL21 cells using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MTGPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reductionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35TTHPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reductionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35TTHPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16483(2-{6-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Bos taurus (Cattle))
COMSATS Institute of Information Technology

LigandPNGBDBM193848(Coumarin-thiazole series I, 6a)copy SMILEScopy InChI
Affinity DataIC50: 2.94E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445K96PubMed
TargetAldo-keto reductase family 1 member A1(Bos taurus (Cattle))
COMSATS Institute of Information Technology

LigandPNGBDBM193864(3-(4-((Butylamino)methyl)-5-thioxo-4,5-dihydro-1,3...)copy SMILEScopy InChI
Affinity DataIC50: 3.36E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2445K96PubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16461(2-(6-bromo-3-{[5-(trifluoromethyl)-1,3-benzothiazo...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50126791(CHEMBL281442 | Cyano-[1-(4-methyl-benzyl)-2-oxo-2,...)copy SMILEScopy InChI
Affinity DataIC50: 3.57E+3nMAssay Description:In vitro inhibitory activity against aldehyde reductase 1 (ALR1) from rat kidney.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0KN9PubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)copy SMILEScopy InChI
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibitory activity was measured against pig kidney aldehyde reductase in the presence of 1 uM compound with 3-pyridine carboxaldehyde as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3FMZPubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35T6FPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16465(2-{3-[(6-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reductionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35TTHPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50363067(CHEMBL1944858)copy SMILEScopy InChI
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human recombinant AKR1A1 expressed in Escherichia coli BL21 cells using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MTGPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16475(2-{5-bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-...)copy SMILEScopy InChI
Affinity DataIC50: 4.70E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16478(2-[5-(benzyloxy)-3-[(4,5,7-trifluoro-1,3-benzothia...)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16460(2-(5-chloro-3-{[5-(trifluoromethyl)-1,3-benzothiaz...)copy SMILEScopy InChI
Affinity DataIC50: 4.90E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16468(2-{3-[(4,6-difluoro-1,3-benzothiazol-2-yl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)copy SMILEScopy InChI
Affinity DataIC50: 5.40E+3nMAssay Description:Tested for in vitro inhibition activity against human aldehyde reductase (AHR)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HH6JBTPubMed
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
Gifu Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)copy SMILEScopy InChI
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibitory concentration against human ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35T6FPubMed
TargetAldo-keto reductase family 1 member A1(Sus scrofa)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50213307(CHEMBL396176 | [(5Z)-5-{[3-(carboxymethoxy)-4-meth...)copy SMILEScopy InChI
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of pig ALR1 assessed as decrease in NADPH absorbance by spectrophotometryMore data for this Ligand-Target Pair
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