Found 263 Enz. Inhib. hit(s) with Target = 'Interferon-induced, double-stranded RNA-activated protein kinase' TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 39nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 66nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 76nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 82nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 99nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 140nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 158nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 301nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 558nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 727nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 3.40E+3nMAssay Description:Competitive inhibition of human recombinant PKRMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 1.00E+4nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataKi: 1.00E+4nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 39nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 66nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 69nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 69nMAssay Description:PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 69nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 76nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 82nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 99nMAssay Description:Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 99nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 116nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
In DepthDetails
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 140nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 158nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 167nMAssay Description:PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 167nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 167nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant human PKR (252 to end residues) using RSRSRSRSRSRSRS as substrate after 40 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 291nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 301nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 306nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
In DepthDetails
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 359nMAssay Description:Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 364nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
In DepthDetails
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 390nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 390nMAssay Description:PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 390nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 475nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
In DepthDetails
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 551nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 551nMAssay Description:PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 551nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 558nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
ALLERGAN, INC.
US Patent
ALLERGAN, INC.
US Patent
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
