Compile Data Set for Download or QSAR
Found 11 Enz. Inhib. hit(s) with Target = 'Peptidoglycan D,D-transpeptidase FtsI'
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50240480((2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 68.9nMAssay Description:Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5RN2PubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
University of Oxford

LigandPNGBDBM50240426((2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazi...)copy SMILEScopy InChI
Affinity DataIC50: 166nMpH: 7.2 T: 2°CAssay Description:An appropriate amount of enzyme (4uM) was pre-incubated with the (5R)- or 5(S)-penicilloic acid in the assay buffer (50mM HEPES-NaOH buffer (pH 7.2) ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1QRKPubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50420259(CEFTAZIDIME)copy SMILEScopy InChI
Affinity DataIC50: 182nMAssay Description:Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5RN2PubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50378857(CEFTOBIPROLE | Zeftera | Zevtera)copy SMILEScopy InChI
Affinity DataIC50: 187nMAssay Description:Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5RN2PubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50350470(CEFEPIME | Maxipime)copy SMILEScopy InChI
Affinity DataIC50: 208nMAssay Description:Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5RN2PubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50213266(CHEBI:471744 | Imipenem | MK-0787)copy SMILEScopy InChI
Affinity DataIC50: 334nMAssay Description:Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5RN2PubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50538667(CHEMBL4634190)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa PBP3 assessed as reduction in fluorescence intensity using Bocillin-protein as fluorescent substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92G5WPubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50538667(CHEMBL4634190)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa PBP3 assessed as reduction in fluorescence intensity of bocillin labeled protein pre-incubated for 20 mins befor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25142S5PubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50578473(CHEMBL4872152)copy SMILES
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa PBP3 assessed as reduction in fluorescence intensity using Bocillin-protein as fluorescent substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92G5WPubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
University of Oxford

LigandPNGBDBM104100((5S)-PA | (5S)-Penicilloic acid)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+5nMpH: 7.2 T: 2°CAssay Description:An appropriate amount of enzyme (4uM) was pre-incubated with the (5R)- or 5(S)-penicilloic acid in the assay buffer (50mM HEPES-NaOH buffer (pH 7.2) ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1QRKPubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
University of Oxford

LigandPNGBDBM104099((5R)-PA | (5R)-Penicilloic acid)copy SMILEScopy InChI
Affinity DataIC50: 1.96E+5nMpH: 7.2 T: 2°CAssay Description:An appropriate amount of enzyme (4uM) was pre-incubated with the (5R)- or 5(S)-penicilloic acid in the assay buffer (50mM HEPES-NaOH buffer (pH 7.2) ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1QRKPubMed