Compile Data Set for Download or QSAR
Found 111 of ic50 for UniProtKB: P14618
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50033731((R)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human N-terminal His6/SUMO-tagged PKM2 expressed in Escherichia coli BL21 using PEP as substrate incubated for 30 mins in p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40XS7PubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597717(CHEMBL3609603)copy SMILES
Affinity DataIC50: 650nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597717(CHEMBL3609603)copy SMILES
Affinity DataIC50: 650nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50033731((R)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl...)copy SMILEScopy InChI
Affinity DataIC50: 800nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50135164(3,4,5-Trihydroxy-benzoic acid (2S,3S)-2-(3,4-dihyd...)copy SMILEScopy InChI
Affinity DataIC50: 850nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicansMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50135169((-)-Catechin gallate | (2S,3R)-2-(3,4-dihydroxyphe...)copy SMILEScopy InChI
Affinity DataIC50: 850nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM7457(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)copy SMILEScopy InChI
Affinity DataIC50: 900nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM7457(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597697(ALKANNIN | CHEBI:2578 | E103)copy SMILES
Affinity DataIC50: 900nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597697(ALKANNIN | CHEBI:2578 | E103)copy SMILES
Affinity DataIC50: 900nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597706(CHEMBL5189727)copy SMILES
Affinity DataIC50: 960nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)copy SMILEScopy InChI
Affinity DataIC50: 990nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)copy SMILEScopy InChI
Affinity DataIC50: 990nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)copy SMILEScopy InChI
Affinity DataIC50: 990nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)copy SMILEScopy InChI
Affinity DataIC50: 1.16E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)copy SMILEScopy InChI
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicansMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50081950(6-Hydroxy-2-phenyl-chromen-4-one | 6-Hydroxyflavon...)copy SMILEScopy InChI
Affinity DataIC50: 1.24E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50260539(CHEMBL80941)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicansMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50049385(5-Hydroxy-2-phenyl-chromen-4-one | 5-Hydroxyflavon...)copy SMILEScopy InChI
Affinity DataIC50: 1.39E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271046(CHEMBL4127005)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50384788(LAPACHOL)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicansMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50009353(1,5,10-triazadecane | 4-azaoctamethylenediamine | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50033731((R)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicansMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271056(CHEMBL4127111)copy SMILEScopy InChI
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597715(CHEMBL4877010)copy SMILES
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597715(CHEMBL4877010)copy SMILES
Affinity DataIC50: 2.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 2.01E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM26664(7-Hydroxy-flavone, 5a | 7-Hydroxyflavone, 11 | 7-h...)copy SMILEScopy InChI
Affinity DataIC50: 2.12E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271044(CHEMBL4125726)copy SMILEScopy InChI
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271058(CHEMBL4128346)copy SMILEScopy InChI
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271043(CHEMBL4128703)copy SMILEScopy InChI
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicansMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271043(CHEMBL4128703)copy SMILEScopy InChI
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271057(CHEMBL4128501)copy SMILEScopy InChI
Affinity DataIC50: 4.23E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271052(CHEMBL4128970)copy SMILEScopy InChI
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271060(CHEMBL4129340)copy SMILEScopy InChI
Affinity DataIC50: 4.93E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597716(CHEBI:2672 | OXYMATRINE | Oxymatrine)copy SMILES
Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271092(CHEMBL4126536)copy SMILEScopy InChI
Affinity DataIC50: 5.08E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271095(CHEMBL4128010)copy SMILEScopy InChI
Affinity DataIC50: 5.28E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271048(CHEMBL4126776)copy SMILEScopy InChI
Affinity DataIC50: 5.89E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271046(CHEMBL4127005)copy SMILEScopy InChI
Affinity DataIC50: 6.26E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM1 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271053(CHEMBL4129306)copy SMILEScopy InChI
Affinity DataIC50: 6.79E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM82190(Salicylic acid derivative, compound 2)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMAssay Description:Primary screening was performed using PKM2 in the presence of FBP. Compounds were chosen as potential "hits" if the compound demonstrated inhibition ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D21WBNUS Patent
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50597707(CHEMBL5171047)copy SMILES
Affinity DataIC50: 8.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271073(CHEMBL4126021)copy SMILEScopy InChI
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271054(CHEMBL4127909)copy SMILEScopy InChI
Affinity DataIC50: 8.78E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50033731((R)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl...)copy SMILEScopy InChI
Affinity DataIC50: 8.82E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
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