Compile Data Set for Download or QSAR
Found 16 Enz. Inhib. hit(s) with all data for entry = 50034288
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359993(CHEMBL1928291)copy SMILEScopy InChI
Affinity DataIC50: 5.54nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359997(CHEMBL1928312)copy SMILEScopy InChI
Affinity DataIC50: 5.93nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)copy SMILEScopy InChI
Affinity DataIC50: 8.90nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359998(CHEMBL1928315)copy SMILEScopy InChI
Affinity DataIC50: 10.8nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359999(CHEMBL1928309)copy SMILEScopy InChI
Affinity DataIC50: 16.6nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359995(CHEMBL1928301)copy SMILEScopy InChI
Affinity DataIC50: 18.5nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359994(CHEMBL1928293)copy SMILEScopy InChI
Affinity DataIC50: 18.7nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359992(CHEMBL1928311)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359996(CHEMBL1928310)copy SMILEScopy InChI
Affinity DataIC50: 43.7nMAssay Description:Inhibition of EGFR using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of Erbb2 using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359992(CHEMBL1928311)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of EGFR autophosphorylation in EGF-stimulated human A431 cells after 1 hr by immunoblottingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of Erbb2 using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50359999(CHEMBL1928309)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of EGFR autophosphorylation in EGF-stimulated human A431 cells after 1 hr by immunoblottingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 820nMAssay Description:Inhibition of VEGFR2 using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2 using poly(Glu,Tyr)4:1 as substrate and [gamma33P]ATP after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J966SRPubMed