Compile Data Set for Download or QSAR
Found 4 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2 [Y641F]' and Ligand = 'BDBM172166'
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.89nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057DPXUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.89nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SB48WPUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.89nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TM3US Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.90nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent