Compile Data Set for Download or QSAR
Found 30 Enz. Inhib. hit(s) with all data for assayid = 1 entry = 9884
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)copy SMILEScopy InChI
Affinity DataIC50: 8.60nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312256(1-{2-[(Cyclobutylamino)methyl]benzyl}-2-thioxo-1,2...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312257(1-{2-[(Cyclopentylamino)methyl]benzyl}-2-thioxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312176(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312251(1-(2-{[(Cyclobutylmethyl)amino]methyl}benzyl)-2-th...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312264(1-[2-(Aminomethyl)-4-(trifluoromethyl)benzyl]-2-th...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312265(1-{2-[(Methylamino)methyl]-4-(trifluoromethyl)benz...)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312258(1-(2-{[(2-Methylpropyl)amino]methyl}benzyl)-2-thio...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)copy SMILEScopy InChI
Affinity DataIC50: 8.80E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312176(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)copy SMILEScopy InChI
Affinity DataIC50: 8.90E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312265(1-{2-[(Methylamino)methyl]-4-(trifluoromethyl)benz...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312256(1-{2-[(Cyclobutylamino)methyl]benzyl}-2-thioxo-1,2...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312251(1-(2-{[(Cyclobutylmethyl)amino]methyl}benzyl)-2-th...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312257(1-{2-[(Cyclopentylamino)methyl]benzyl}-2-thioxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312264(1-[2-(Aminomethyl)-4-(trifluoromethyl)benzyl]-2-th...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312258(1-(2-{[(2-Methylpropyl)amino]methyl}benzyl)-2-thio...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)copy SMILEScopy InChI
Affinity DataIC50: 6.80E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent