Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'Bcl2-associated agonist of cell death' and Ligand = 'BDBM50270877'
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)copy SMILEScopy InChI
Affinity DataKi: <0.5nMAssay Description:Binding affinity to BH3 binding groove of BclXLMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58M4HPubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR51BHUS Patent
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)copy SMILEScopy InChI
Affinity DataKd:  55nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR51BHUS Patent