Compile Data Set for Download or QSAR
Found 44 Enz. Inhib. hit(s) with Target = 'DNA gyrase subunit A/B' and Ligand = 'BDBM21690'
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 45nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC942ZPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 122nMAssay Description:Inhibition of Escherichia coli DNA gyrase super-coiling activity using relaxed pNO1 DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T1573JPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of Escherichia coli DNA gyrase after 1 hr by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TZWPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M679KPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed PBR322 plasmid DNA as substrate incubated for 30 mins by ethidium bromide staining based agar...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8QN5PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of Escherichia coli gyraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N80RCPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 230nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X06C35PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 270nMAssay Description:Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FB6PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of reconstituted Escherichia coli DNA gyrase subunit AB assessed as reduction of DNA supercoiling activity using pBR322 DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348KKMPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of DNA gyrase supercoiling in Escherichia coli ATCC 25922More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30W3PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against wild type Escherichia coli gyraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3R76PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of Escherichia coli DNA gyrase A2B2 using relaxed pNO1 as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765HX2PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 440nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X06BPCPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2MQSPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against DNA gyrase enzyme was determined by supercoiling assay with Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX49Z2PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 600nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R2159MPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 661nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2183BM1PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 830nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activity using pBR322 as substrate incubated for 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ0D6NPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 2.05E+3nMAssay Description:Inhibitory effect against Escherichia coli Gyrase in Supercoiling assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SX6GZPPubMedDrugBank
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 3.84E+3nMMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using pBR322 as substrate after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 4.82E+3nMAssay Description:Inhibition of Wild Type DNA gyrase Supercoiling Activity in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R2144ZPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in enzyme-mediated DNA supercoiling using relaxed pBR322 substrate incubated for 60 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9N7JPubMedDrugBank
TargetDNA gyrase subunit A/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 6.30E+3nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2988599PubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 9.35E+3nMAssay Description:In vitro inhibitory concentration against DNA gyrase from Escherichia coli H560More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B61N6PubMedDrugBank
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using pBR322 DNA as substrate after 30 mins by ethidium bromide staining based a...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pBR322 as substrate by gel electrophoresisMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus subsp. aureus Mu50)
Wockhardt Limited

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of supercoiling activity of DNA gyrase from Staphylococcus aureus ISP 794More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+4nMAssay Description:50% inhibitory concentration against DNA-gyraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B62BKPubMedDrugBank
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of the gyrase mediated cleavage of supercoiled DNAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F191XXPubMedDrugBank
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 2.64E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pBR322 DNA as substrate incubated for 45 mins by agarose gel electrophoresis methodMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+4nMMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of Staphylococcus aureus Gyrase supercoiling activity assessed as reduction in supercoiling pBR322 DNA by measuring relaxation by bromophe...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 3.15E+4nMAssay Description:Inhibition of DNA supercoiling activity of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP)

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 3.77E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase supercoiling activity using relaxed pBR322 as substrate after 30 mins by agarose gel electrophore...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 3.92E+4nMAssay Description:Inhibition of Staphylococcus aureus wild type DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 3.93E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using relaxed pNO1 as substrate by gel based fluorescence assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 6.17E+4nMAssay Description:Inhibition of Staphylococcus aureus wild-type DNA gyrase supercoiling activity assessed as effect on conversion of relaxed pBR322 DNA to supercoiled ...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis ass...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.21E+5nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using relaxed pHOT-1 DNA as substrate after 60 mins by ethidium bromide-based ge...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.28E+5nMAssay Description:Inhibition of Staphylococcus aureus N-terminal His6-tagged DNA gyrase subunit GyrA/GyrB supercoiling activity expressed in Escherichia coli BL21 (DE3...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.28E+5nMAssay Description:Inhibition of wild type Staphylococcus aureus DNA gyrase subunit 2GyrA/2GyrB assessed as pBR322 supercoiling after 1 hrMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 3.07E+5nMAssay Description:Inhibition of Quinolone resistant gyrase Supercoiling Activity in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R2144ZPubMedDrugBank