Affinity DataKi: 0.0250nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataKi: 0.143nMAssay Description:Binding affinity of the compound was reported with purified recombinant P. carnii Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibitory activity against Wild-type human DHFRMore data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibitory concentration against dihydrofolate reductase of Mycobacterium aviumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibitory concentration against Mycobacterium avium dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium aviumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 0.53-0.70More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from rat liver (rl)More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Dihydrofolate reductase (DHFR) of in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity of the compound was tested against rat DHFR*More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 microM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inihibitory concentration against rat liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against Rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Dihydrofolate Reductase of Rat Liver.More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity of the compound against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Concentration inhibiting rat liver dihydrofolate reductase .More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Lactobacillus casei)
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity of the compound was determined against dihydrofolate reductase in mammalians.(high potency)More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Rat liver (rl)More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of dihydrofolate reductase from rat liver.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using 9 uM DHFA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using 18 uM DHFA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range : 2.9-3.9More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibitory activity of the compound against rat dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition Dihydrohydrofolate reductase(DHFR) of rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibitory concentration against dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 4.0-4.6More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondiiMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibitory concentration against dihydrofolate reductase DHFR from rat liver.More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of dihydrofolate reductase in pneumocystis carinii.More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of dihydrofolate reductase from toxoplasma gondii.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School of Medicine
Curated by ChEMBL
Indiana University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis cariniiMore data for this Ligand-Target Pair