Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM26521'
TargetDihydrofolate reductase(Bacillus anthracis)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM26521(6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-y...)copy SMILEScopy InChI
Affinity DataKi:  320nMAssay Description:Inhibition of wild type Bacillus anthracis recombinant DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM26521(6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29P7PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

LigandPNGBDBM26521(6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH oxidation at an absorbance of 340 nm over several minutes. All...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P8496HPubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

LigandPNGBDBM26521(6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29P7PubMed
TargetDihydrofolate reductase(Bacillus anthracis)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM26521(6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 942nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH oxidation at an absorbance of 340 nm over several minutes. All...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bacillus anthracis)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM26521(6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 942nMAssay Description:Inhibition of wild type Bacillus anthracis recombinant DHFRMore data for this Ligand-Target Pair