Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase XIAP' and Ligand = 'BDBM156129'
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astex Therapeutics Limited

US Patent
LigandPNGBDBM156129(US9018214, 180)copy SMILEScopy InChI
Affinity DataIC50: 44nMpH: 7.5 T: 2°CAssay Description:Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9FXQUS Patent
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astex Therapeutics Limited

US Patent
LigandPNGBDBM156129(US9018214, 180)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of SMAC-derived peptide abuRPFK (5 and 6FAM)-amide interaction with XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9DX7PubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astex Therapeutics Limited

US Patent
LigandPNGBDBM156129(US9018214, 180)copy SMILEScopy InChI
Affinity DataEC50:  120nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9DX7PubMed