Compile Data Set for Download or QSAR
Found 7 Enz. Inhib. hit(s) with Target = 'Insulin receptor' and Ligand = 'BDBM482158'
TargetInsulin receptor(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human InsR using myelin basic protein as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NK3H0QPubMed
TargetInsulin receptor(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of InsRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X58QSPubMed
TargetInsulin receptor(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of TEL-fused insulin receptor (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G1627JPubMed
TargetInsulin receptor(Rattus norvegicus (rat))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of InsR phosphorylation in rat H4-2E cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02K2PubMed
TargetInsulin receptor(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant InsRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02K2PubMed
TargetInsulin receptor(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)copy SMILEScopy InChI
Affinity DataKd:  2.40nMAssay Description:Binding constant for INSR kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed
TargetInsulin receptor(Homo sapiens (Human))
ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)copy SMILEScopy InChI
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of InsR by cellular assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X58QSPubMed