Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with Target = 'Kelch-like ECH-associated protein 1' and Ligand = 'BDBM50006933'
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50006933(CHEMBL3134422)copy SMILEScopy InChI
Affinity DataIC50: 193nMAssay Description:Binding affinity to human KEAP1 Kelch domain (322 to 609 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3R4SPubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50006933(CHEMBL3134422)copy SMILEScopy InChI
Affinity DataIC50: 194nMAssay Description:Inhibition of recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS interaction with Nrf2 assessed ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377BPQPubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50006933(CHEMBL3134422)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Displacement of AF647-9-mer ETGE peptide from recombinant human biotinylated KEAP1 Kelch domain (322 to 609 residues) expressed in Escherichia coli B...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q269774XPubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50006933(CHEMBL3134422)copy SMILEScopy InChI
Affinity DataEC50:  395nMAssay Description:Displacement of FITC-LDEETGEFL-NH2 from Keap1 Kelch domain (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X3500XPubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50006933(CHEMBL3134422)copy SMILEScopy InChI
Affinity DataKd:  21nMAssay Description:Binding affinity to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21(DE3)pLysS by SPR-based solution com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377BPQPubMed