Compile Data Set for Download or QSAR
Found 54 of ic50 data for polymerid = 50007164
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239101(US10195181, Example 2.2 | US9403810, 2.2)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239101(US10195181, Example 2.2 | US9403810, 2.2)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9S2BPubMed
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM50193010(CHEMBL3949800)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9S2BPubMed
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239117(US10195181, Example 22c | US9403810, 22)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239094(US10195181, Example 1.3 | US9403810, 1.3)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239094(US10195181, Example 1.3 | US9403810, 1.3)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9S2BPubMed
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239092(US10195181, Example 1.1 | US9403810, 1.1)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239099(US10195181, Example 2 | US9403810, 2)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM50193011(CHEMBL3945602)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9S2BPubMed
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239091(US10195181, Example 1 | US9403810, 1)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239095(US10195181, Example 1.4 | US9403810, 1.4)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239105(US10195181, Example 6 | US9403810, 6)copy SMILEScopy InChI
Affinity DataIC50: 5.70nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239105(US10195181, Example 6 | US9403810, 6)copy SMILEScopy InChI
Affinity DataIC50: 5.70nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9S2BPubMed
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239096(US10195181, Example 1.5 | US9403810, 1.5)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239102(US10195181, Example 3 | US9403810, 3)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239097(US10195181, Example 1.6 | US9403810, 1.6)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239093(US10195181, Example 1.2 | US9403810, 1.2)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239107(US10195181, Example 7 | US9403810, 7)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239106(US10195181, Example 6.1 | US9403810, 6.1)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239098(US10195181, Example 1.7 | US9403810, 1.7)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM331990(5-((2S,6R)-6-(tert-butyl)tetrahydro-2H-pyran-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239108(US10195181, Example 8 | US9403810, 8)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239110(US10195181, Example 10 | US9403810, 10)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239109(US10195181, Example 9 | US9403810, 9)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239100(US10195181, Example 2.1 | US9403810, 2.1)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM331992(N-(2-cyclohexyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239122(US10195181, Example 12 | US9403810, 12)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239103(US10195181, Example 4 | US9403810, 4)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM332001(A mixture of 5-((2R,4S)-4-(2-bromopropan-2-yl)tetr...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239115(US10195181, Example 20 | US9403810, 20)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239135(US10195181, Example 24b | US9403810, 24a)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM331988(US10195181, Example 15a | US10195181, Example 15b)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239113(US10195181, Example 13a | US9403810, 13b)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239104(US10195181, Example 5 | US9403810, 5)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239135(US10195181, Example 24b | US9403810, 24a)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239135(US10195181, Example 24b | US9403810, 24a)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239117(US10195181, Example 22c | US9403810, 22)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239111(US10195181, Example 11 | US9403810, 11)copy SMILEScopy InChI
Affinity DataIC50: 420nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239130(US10195181, Example 21.2 | US9403810, 21.2)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239117(US10195181, Example 22c | US9403810, 22)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239121(US10195181, Example 26 | US9403810, 26)copy SMILEScopy InChI
Affinity DataIC50: 580nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM331988(US10195181, Example 15a | US10195181, Example 15b)copy SMILEScopy InChI
Affinity DataIC50: 630nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM239116(US10195181, Example 21.1 | US9403810, 21.1)copy SMILEScopy InChI
Affinity DataIC50: 630nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM331984(A mixture of 5-((2S,4R,6R)-6-(tert-butyl)-4-methox...)copy SMILEScopy InChI
Affinity DataIC50: 640nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM331984(A mixture of 5-((2S,4R,6R)-6-(tert-butyl)-4-methox...)copy SMILEScopy InChI
Affinity DataIC50: 730nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)copy SMILEScopy InChI
Affinity DataIC50: 840nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM331991(A mixture of 5-((2R,6S)-6-(tert-butyl)tetrahydro-2...)copy SMILEScopy InChI
Affinity DataIC50: 980nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28054Q2US Patent
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