Compile Data Set for Download or QSAR
Found 361 of ic50 for UniProtKB: P25024
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50503347(CHEMBL4442431)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CXCR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR8081PubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50169045((R)-2-(4-isobutylphenyl)-N-(methylsulfonyl)propana...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862HKRPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50115286(CHEMBL3609016)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V989VFPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50200880((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862HKRPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50236053((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639TV2PubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50115227(CHEMBL3609018)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V989VFPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50211458((R)-2-hydroxy-3-(2-(1-(4-isopropylfuran-2-yl)propy...)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8RH5PubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50200882((R)-3-(2-(2,2-dimethyl-1-(5-methylfuran-2-yl)propy...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5GVRPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13066(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of wild type CXCR1 transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated for 15 mins measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V124TWPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50187003(3-(3,4-dioxo-2-(pentan-3-ylamino)cyclobut-1-enylam...)copy SMILEScopy InChI
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639TV2PubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385556(US10287278, Example 18 | US10287278, Example 19 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385552(US10287278, Example 14 | US10287278, Example 15 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385550(US10287278, Example 12 | US10287278, Example 13 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385550(US10287278, Example 12 | US10287278, Example 13 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385540(3-{4-Chloro-2-hydroxy-3-methane[(N-methyl)sulfoxim...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM441948(US10647706, Example 1)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385549(US10287278, Example 11 | US10647706, Example 11)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385548(US10287278, Example 10 | US10647706, Example 10)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385547(US10287278, Example 9 | US10647706, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385546(US10287278, Example 16 | US10287278, Example 17 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385545(US10287278, Example 7 | US10647706, Example 7)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385544(US10287278, Example 6 | US10647706, Example 6)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385543(US10287278, Example 5 | US10647706, Example 5)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385542(US10287278, Example 4 | US10647706, Example 4)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385541(US10287278, Example 3 | US10647706, Example 3)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385540(3-{4-Chloro-2-hydroxy-3-methane[(N-methyl)sulfoxim...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM291181(6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfu...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222WT6US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385552(US10287278, Example 14 | US10287278, Example 15 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385546(US10287278, Example 16 | US10287278, Example 17 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236813(US9388149, 10 (Diastereoisomer 1) | US9388149, 10 ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMT: 2°CAssay Description:⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W990KUS Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385556(US10287278, Example 18 | US10287278, Example 19 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM385546(US10287278, Example 16 | US10287278, Example 17 | ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:To evaluate the direct interaction of the CXCR2 or CXCR1 receptor with β-arrestin 2, a test of β-arrestin 2 recruitment for CXCR2 or CXCR1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1NM8US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50193973((R)-1-(3-(3-(3-(2-bromophenyl)-2-cyanoguanidino)-6...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]IL8 from CXCR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9HWDPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50150572(1-(2-Bromo-phenyl)-3-(2,4-dihydroxy-phenyl)-urea |...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibitory concentration against interleukin-8 receptor of human neutrophils by using [125I]-IL-8 (0.125 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4P4MPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50203012(1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea ...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Antagonist activity at CXCR1 assessed as inhibition of CXCL8 binding by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862HKRPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50200878((R)-3-(2-(1-(furan-2-yl)propylamino)-3,4-dioxocycl...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5GVRPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236791(US9388149, 22 | US9580412, Example 22)copy SMILEScopy InChI
Affinity DataIC50: 30nMT: 2°CAssay Description:⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W990KUS Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236791(US9388149, 22 | US9580412, Example 22)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222WT6US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V989VFPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of CXCR1 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q200GPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50200888((R)-2-hydroxy-N,N-dimethyl-3-(2-(2-methyl-1-(5-met...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5GVRPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236787(US9388149, 18 | US9580412, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 36nMT: 2°CAssay Description:⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W990KUS Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50200880((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Displacement of [125I]hCXCL8 from human CXCR1 receptor expressed in BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5GVRPubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50200880((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236787(US9388149, 18 | US9580412, Example 18)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222WT6US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50187001(3-(2-hydroxy-4-nitrophenylamino)-4-(phenylamino)cy...)copy SMILEScopy InChI
Affinity DataIC50: 36nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639TV2PubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236788(US9388149, 19 | US9580412, Example 19)copy SMILEScopy InChI
Affinity DataIC50: 42nMT: 2°CAssay Description:⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W990KUS Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236788(US9388149, 19 | US9580412, Example 19)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222WT6US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236789(US9388149, 20 | US9580412, Example 20)copy SMILEScopy InChI
Affinity DataIC50: 43nMT: 2°CAssay Description:⿿PathHunter HEK293-CXCR2⿝ or ⿿U2OS hCXCR1 β-arrestin⿝ cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W990KUS Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM236789(US9388149, 20 | US9580412, Example 20)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222WT6US Patent
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