Compile Data Set for Download or QSAR
Found 505 of ic50 data for polymerid = 969
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7MPDPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK5 (unknown origin) expressed in Sf9 insect cells using biotinylated peptide derived Histone H1 as substrate incubated for 1 hr in pr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154MVTPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50468264(CHEMBL4292930)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK5 (unknown origin) expressed in Sf9 cells using histone H1 derived biotinylated peptide and 33P-ATP incubated for 1 hr b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S1856WPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q801KPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
In DepthDetails
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50612866(CHEMBL5266005)copy SMILES
Ligand Info
In DepthDetails
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
In DepthDetails
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK5 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated-histone H1 as substrate incubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q21J2PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK5 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated peptide as substrate after 1 hr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0C84PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5C86PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK5 (unknown origin) expressed in baculovirus infected Sf9 cells using biotinylated Histone H1 peptide as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3K3WPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB56K3PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50154931(CHEMBL3775792)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ927CPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant CDK5 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated Histone H1 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73GP8PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125VNCPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK5 (unknown origin) expressed in baculovirus infected Sf9 insect cells using histone H1 as substrate after 1 hr by liquid scintillati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M399KPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50363196(CHEMBL1944698)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human GST-tagged CDK5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G73GP8PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CDK5/P35More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M94FZPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM444579(US10662186, Compound 101 | US10662186, Compound 10...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX4FKSUS Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM494018(US10988476, Compound I-101)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PR8047US Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK5/P25 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M94FZPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50363196(CHEMBL1944698)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human CDK5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB56K3PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against Escherichia coli TEM-3 Beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50155213(1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-8-yl-u...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MFBPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM6939(4-hydroxy-N-({[3-(4-methoxyphenyl)-4-oxo-2H,4H-ind...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3GBSPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50154932(CHEMBL3774632)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ927CPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50378826(CHEMBL1241758)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3GBSPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50154928(CHEMBL3775509)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ927CPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM7478(2-chloro-4-[(2-{[(1R)-1-(hydroxymethyl)-2-methylpr...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human cdk5/p35More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8MMGPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50570973(CHEMBL4864688)copy SMILES
Affinity DataIC50: 7nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348Q6BPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50155231(2-(1H-Benzoimidazol-5-yl)-N-(5-cyclobutyl-thiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MFBPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM444620(US10662186, Compound 202 | US10988476, Compound I-...)copy SMILEScopy InChI
Affinity DataIC50: 7.17nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX4FKSUS Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM444620(US10662186, Compound 202 | US10988476, Compound I-...)copy SMILEScopy InChI
Affinity DataIC50: 7.17nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PR8047US Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50155209(1-(5-Cyclobutyl-thiazol-2-yl)-3-isoquinolin-5-yl-u...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MFBPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50154925(CHEMBL3775470)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ927CPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM444613(US10662186, Compound 176 | US10988476, Compound I-...)copy SMILEScopy InChI
Affinity DataIC50: 8.37nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX4FKSUS Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM444613(US10662186, Compound 176 | US10988476, Compound I-...)copy SMILEScopy InChI
Affinity DataIC50: 8.37nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PR8047US Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50154930(CHEMBL3774932)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ927CPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50511926(CHEMBL4442620)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB56K3PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50155236(CHEMBL363954 | N-(5-Cyclobutyl-thiazol-2-yl)-2-qui...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MFBPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3BR6PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM556330(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)copy SMILES
Affinity DataIC50: 11.3nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1PTPUS Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM444549(US10662186, Compound 69 | US10988476, Compound I-6...)copy SMILEScopy InChI
Affinity DataIC50: 11.4nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX4FKSUS Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM444549(US10662186, Compound 69 | US10988476, Compound I-6...)copy SMILEScopy InChI
Affinity DataIC50: 11.4nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PR8047US Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50155235(CHEMBL186470 | N-(5-Cyclobutyl-thiazol-2-yl)-2-(2-...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MFBPubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50113281(AT-7519)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB56K3PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM50155207(1-(5-Cyclobutyl-thiazol-2-yl)-3-quinolin-5-yl-urea...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D50MFBPubMed
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