Compile Data Set for Download or QSAR

Found 20 hits of Enzyme Inhibition Constant Data   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22418(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)copy SMILEScopy InChI
Affinity DataKi:  830nM EC50:  385nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22412(2-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  990nM EC50:  2.04E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22405(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  1.27E+3nM EC50:  620nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22415(5-(3,4-dimethoxyphenyl)-2-[(1R,2S,3S,5S)-8-methyl-...)copy SMILEScopy InChI
Affinity DataKi:  1.39E+3nM EC50: >6.90E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22408(5-(4-fluorophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4-...)copy SMILEScopy InChI
Affinity DataKi:  1.63E+3nM EC50:  4.87E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22399(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  1.70E+3nM EC50:  690nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22398(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  1.84E+3nM EC50:  750nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22407(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  1.91E+3nM EC50:  4.21E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22411(2-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  1.97E+3nM EC50:  1.55E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22410(5-(3-bromophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4-m...)copy SMILEScopy InChI
Affinity DataKi:  2.21E+3nM EC50:  3.24E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22403(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  2.27E+3nM EC50:  582nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22406(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  2.30E+3nM EC50:  6.50E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22404(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  2.51E+3nM EC50:  650nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22402(5-(3-bromophenyl)-2-[(1R,2S,3S,5S)-3-(4-chlorophen...)copy SMILEScopy InChI
Affinity DataKi:  2.53E+3nM EC50:  2.30E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22400(5-(4-chlorophenyl)-2-[(1R,2S,3S,5S)-3-(4-chlorophe...)copy SMILEScopy InChI
Affinity DataKi:  2.70E+3nM EC50:  912nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22409(5-(4-chlorophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4-...)copy SMILEScopy InChI
Affinity DataKi:  2.87E+3nM EC50:  1.17E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22401(5-(4-bromophenyl)-2-[(1R,2S,3S,5S)-3-(4-chlorophen...)copy SMILEScopy InChI
Affinity DataKi:  3.29E+3nM EC50:  960nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22413(5-(4-methoxyphenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4...)copy SMILEScopy InChI
Affinity DataKi:  3.63E+3nM EC50:  1.81E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22419(5-(4-bromophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3-(4-m...)copy SMILEScopy InChI
Affinity DataKi:  4.24E+3nM EC50:  1.82E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22414(5-(3,4-dichlorophenyl)-2-[(1R,2S,3S,5S)-8-methyl-3...)copy SMILEScopy InChI
Affinity DataKi: >6.10E+3nM EC50:  4.00E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
Displayed 1 to 50 (of 117 total ) | Next | Last >>* indicates data uncertainty>20%