Compile Data Set for Download or QSAR

Found 24 hits of Enzyme Inhibition Constant Data   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14169(4-Iodobenzo[b]thiophene-2-carboxamidine | APC-6860...)copy SMILEScopy InChI
Affinity DataKi:  210nM ΔG°:  -37.7kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM14169(4-Iodobenzo[b]thiophene-2-carboxamidine | APC-6860...)copy SMILEScopy InChI
Affinity DataKi:  440nM ΔG°:  -35.9kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nM ΔG°:  -33.9kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14169(4-Iodobenzo[b]thiophene-2-carboxamidine | APC-6860...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+3nM ΔG°:  -32.9kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)copy SMILEScopy InChI
Affinity DataKi:  2.30E+3nM ΔG°:  -31.9kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)copy SMILEScopy InChI
Affinity DataKi:  9.90E+3nM ΔG°:  -28.3kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+4nM ΔG°:  -27.3kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14169(4-Iodobenzo[b]thiophene-2-carboxamidine | APC-6860...)copy SMILEScopy InChI
Affinity DataKi:  1.68E+4nM ΔG°:  -27.0kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14169(4-Iodobenzo[b]thiophene-2-carboxamidine | APC-6860...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+4nM ΔG°:  -26.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+4nM ΔG°:  -26.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)copy SMILEScopy InChI
Affinity DataKi:  2.10E+4nM ΔG°:  -26.4kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)copy SMILEScopy InChI
Affinity DataKi:  2.10E+4nM ΔG°:  -26.4kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14169(4-Iodobenzo[b]thiophene-2-carboxamidine | APC-6860...)copy SMILEScopy InChI
Affinity DataKi:  3.00E+4nM ΔG°:  -25.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)copy SMILEScopy InChI
Affinity DataKi:  3.40E+4nM ΔG°:  -25.2kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)copy SMILEScopy InChI
Affinity DataKi:  5.80E+4nM ΔG°:  -23.9kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)copy SMILEScopy InChI
Affinity DataKi:  6.30E+4nM ΔG°:  -23.7kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)copy SMILEScopy InChI
Affinity DataKi:  8.00E+4nM ΔG°:  -23.1kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)copy SMILEScopy InChI
Affinity DataKi:  9.70E+4nM ΔG°:  -22.7kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)copy SMILEScopy InChI
Affinity DataKi:  1.10E+5nM ΔG°:  -22.4kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)copy SMILEScopy InChI
Affinity DataKi:  3.20E+5nM ΔG°:  -19.7kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)copy SMILEScopy InChI
Affinity DataKi:  3.60E+5nM ΔG°:  -19.5kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)copy SMILEScopy InChI
Affinity DataKi:  7.50E+5nM ΔG°:  -17.7kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMedMMDB
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)copy SMILEScopy InChI
Affinity DataKi:  1.60E+6nM ΔG°:  -15.8kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)copy SMILEScopy InChI
Affinity DataKi:  1.80E+6nM ΔG°:  -15.5kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NG4NWCPubMed
* indicates data uncertainty>20%