Compile Data Set for Download or QSAR

Found 16 hits of Enzyme Inhibition Constant Data   

TargetInsulin receptor(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50011995((Hydroxy-naphthalen-2-yl-methyl)-phosphonic acid |...)copy SMILEScopy InChI
Affinity DataKi:  9.50E+4nMAssay Description:Non-competitive inhibition of human placental insulin receptor expressed in CHO cell membrane assessed as decrease in insulin-stimulated A2 phosphory...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant pp60c-src expressed in baculovirus infected Sf9 insect cells using poly(Glu,Tyr) 4:1 as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50303801(CHEMBL571546 | N-benzyl-2-(5-(4-(2-morpholinoethox...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as inhibition of cell growth in presence of 0.5% FCSMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50303801(CHEMBL571546 | N-benzyl-2-(5-(4-(2-morpholinoethox...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as inhibition of cell growth in presence of 1.5% FCS by BrdU incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mus musculus (Mouse))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50517924(KX-02 | KX-2361 | Kx2-361)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of Src autophosphorylation in mouse GL261 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50303801(CHEMBL571546 | N-benzyl-2-(5-(4-(2-morpholinoethox...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50303801(CHEMBL571546 | N-benzyl-2-(5-(4-(2-morpholinoethox...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of BCR/ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as reduction in BrdU incorporation after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50517923(CHEMBL4452185)copy SMILEScopy InChI
Affinity DataIC50: 118nMAssay Description:Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as inhibition of cell growth in presence of 1.5% FCS by BrdU incorporation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50517922(CHEMBL4531095)copy SMILEScopy InChI
Affinity DataIC50: 269nMAssay Description:Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as inhibition of cell growth in presence of 1.5% FCS by BrdU incorporation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50517925(CHEMBL4436308)copy SMILEScopy InChI
Affinity DataIC50: 349nMAssay Description:Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as inhibition of cell growth in presence of 1.5% FCS by BrdU incorporation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetInsulin receptor(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50011995((Hydroxy-naphthalen-2-yl-methyl)-phosphonic acid |...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human placental insulin receptor expressed in CHO cells assessed as decrease in insulin-stimulated [3H]-2-deoxyglucose uptake preincuba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50086684(3,6-Dihydroxy-naphthalene-2-carboxylic acid (3-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of full length human recombinant pp60c-src using RR-SRC as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50086685(5-Hydroxy-1H-indole-2-carboxylic acid 3-hydroxy-be...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of full length human recombinant pp60c-src using RR-SRC as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50517924(KX-02 | KX-2361 | Kx2-361)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Athenex Inc.

Curated by ChEMBL
LigandPNGBDBM50303801(CHEMBL571546 | N-benzyl-2-(5-(4-(2-morpholinoethox...)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89GT1PubMed
* indicates data uncertainty>20%