Reaction Details  Report a problem with these data
Target
Tyrosine-protein kinase JAK1 [866-1154]
Ligand
BDBM294911
Substrate
n/a
Meas. Tech.
Biochemical Activity Assay
IC50
0.200±n/a nM
Citation
 Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Aza-indazole compounds for use in tendon and/or ligament injuries US Patent  US11203595 Publication Date 12/21/2021
Target
Name:
Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:
JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:
Protein
Mol. Mass.:
33185.74
Organism:
Homo sapiens (Human)
Description:
P23458[866-1154]
Residue:
289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM294911
Synonyms:
US10112907, Example 00020 | US10766894, Compound TABLE 1.5 | US11203595, TABLE 1.5
Type:
Small organic molecule
Emp. Form.:
C14H14ClFN8
Mol. Mass.:
348.766
SMILES:
C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1 |r|
Structure:
Search PDB for entries with ligand similarity: