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Target
Purine nucleoside phosphorylase
Ligand
BDBM50039552
Substrate
n/a
Meas. Tech.
ChEMBL_162190 (CHEMBL766710)
Ki
210±n/a nM
Citation
 Guida, WC; Elliott, RD; Thomas, HJ; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Ealick, SE; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics. J Med Chem 37:1109-14 (1994) [PubMed]
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50039552
Synonyms:
CHEMBL267312 | [3,3-Dimethyl-5-(6-oxo-1,6-dihydro-purin-9-yl)-pentyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H19N4O4P
Mol. Mass.:
314.2774
SMILES:
CC(C)(CCn1cnc2c1nc[nH]c2=O)CCP(O)(O)=O
Structure:
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