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Target
Purine nucleoside phosphorylase
Ligand
BDBM50046218
Substrate
n/a
Meas. Tech.
ChEBML_153325
IC50
4.1±n/a nM
Citation
 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. J Med Chem 36:55-69 (1993) [PubMed]
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50046218
Synonyms:
2-Amino-6-[(3-methyl-thiophen-2-ylmethyl)-amino]-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL348923
Type:
Small organic molecule
Emp. Form.:
C12H13N5OS
Mol. Mass.:
275.33
SMILES:
Cc1ccsc1CNc1cc2nc(N)[nH]c(=O)c2[nH]1
Structure:
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