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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50363309
Substrate
n/a
Meas. Tech.
ChEMBL_801009 (CHEMBL1948783)
IC50
1.2±n/a nM
Citation
 Herberich, B; Jackson, C; Wurz, RP; Pettus, LH; Sherman, L; Liu, Q; Henkle, B; Saris, CJ; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Identification of triazolopyridazinones as potent p38a inhibitors. Bioorg Med Chem Lett 22:1226-9 (2012) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50363309
Synonyms:
CHEMBL1945726
Type:
Small organic molecule
Emp. Form.:
C24H20ClF2N5O2
Mol. Mass.:
483.898
SMILES:
CCn1n2c(nnc2cc(-c2cc(cc(F)c2C)C(=O)NC2CC2)c1=O)-c1c(F)cccc1Cl |(-1.33,-50.07,;-2.87,-50.05,;-3.63,-48.71,;-5.17,-48.7,;-6.22,-49.83,;-7.62,-49.19,;-7.44,-47.66,;-5.93,-47.35,;-5.16,-46.02,;-3.61,-46.03,;-2.82,-44.71,;-1.29,-44.72,;-.51,-43.4,;-1.27,-42.06,;-2.81,-42.05,;-3.58,-40.71,;-3.59,-43.37,;-5.13,-43.37,;1.03,-43.41,;1.81,-42.09,;1.79,-44.75,;3.33,-44.77,;4.65,-45.56,;4.67,-44.02,;-2.84,-47.38,;-1.3,-47.39,;-6.22,-51.37,;-4.89,-52.14,;-3.56,-51.37,;-4.9,-53.69,;-6.24,-54.45,;-7.57,-53.67,;-7.56,-52.13,;-8.89,-51.35,)|
Structure:
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