Reaction Details 
Report a problem with these data
Report a problem with these dataTarget
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50567964
Substrate
n/a
Meas. Tech.
DHODH Kinetic Analysis
IC50
>100000±n/a nM
Citation
Phillips, M; Palmer, M; Charman, SA; Watts, KS; Gerasyuto, AI; Krilov, G Anti-malarial agents US Patent US11903936 Publication Date 2/20/2024More Info.:
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
80875.72
Organism:
Dog
Description:
A0A8I3N262
Residue:
740
Sequence:
MAWRQLKKRVQDAVVILGGGGLLFTSYLTAMGDEHFYAEHLMPAMQRLLDPESAHRLAVRVTSLGLLPRATFQESDMLEVRVLGHRFRNPIGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLLARQEKQARLTEEGLPLGINLGKNKTSVDAAADYTEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRHLLAKVLQERDALQGAHKPAVLVKIAPDLTAQDKEDIASVVKELGIDGLIITNTTVSRPASLQGALRSEIGGLSGKPLRDLSTQTIREMYALTQGGVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTYRGPPVVGMIKRELEALLKEQGFTRITDAIGADHRRALGAVIALLLWGQLFAEDTGSEATNNTEVSLPKPPVIENGYVEHMIRYQCKPFYKLHTEGDGVYTLNSEKHWTNKAVGEKLPECEAVCGKPKNPVDQVQRIMGGSVDAKGSFPWQAKMVSHHNLTSGATLINEQWLLTTAKNLFLGHKDDAKANDIAPTLKLYVGKNQLVEVEKVVLHPDYSKVDIGLIKLKQKVPIDERVMPICLPSKDYAEVGRIGYVSGWGRNSNFNFTELLKYVMLPVADQDKCVQHYEGSTVPEKKSPKSPVGVQPILNEHTFCAGMSKFQEDTCYGDAGSAFAVHDQDEDTWYAAGILSFDKSCTVAEYGVYVKVPSVLAWVQETIAGN
Inhibitor
Name:
BDBM50567964
Synonyms:
CHEMBL4858336 | US11903936, Compound 29
Type:
Small organic molecule
Emp. Form.:
C19H19F3N4O2
Mol. Mass.:
392.375
SMILES:
CC(NC(=O)c1[nH]cc(Cc2ccc(nc2)C(F)(F)F)c1C)c1cc(C)on1
Structure:
